5 Best Urolithin A Supplements for Healthy Aging and Muscle Health
Urolithin A, a powerful metabolite from pomegranates, has gained attention for its potential anti-aging benefits. But with so many Urolithin A supplements available, choosing the right one can be overwhelming. In this comprehensive review, we'll compare top brands such as Timeline, Neurogan Health, Pure Encapsulations, Sundhedsliv, and Totaria. We'll also discuss key factors to consider when selecting a high-quality Urolithin A supplement, helping you make an informed decision.
Before exploring further, please read the disclaimer located at the end of this webpage.
Comparison Table of 5 Urolithin A Supplements
|
Brand |
Product |
Brand’s Insight |
Quality Certification & Testing Results |
Urolithin A Content |
Other Ingredients (Yes/No) |
Purity |
Price |
|
Timeline |
Mitopure Urolithin A 500mg - 60 Servings |
Healthy Aging Supplements Brand |
NSF Certified for Sport, Clean Label Project Certified, Gluten-Free, Non-GMO |
500mg |
No |
Very High |
$112.5 |
|
Neurogan |
Health Urolithin A Capsules 1000mg - 60 Servings |
Enhancing Cellular Health Through Advanced Ingredients And Cutting-Edge Technologies |
GMP-certified, Third-party tested |
1000mg |
No |
High |
$80 |
|
Pure Encapsulations |
Renual Urolithin A 460mg - 30 Servings |
Pure Ingredients Supplements |
Third-party tested, Free of common allergens |
460mg |
Yes (Trans-Resveratrol, CoQ10) |
High |
$73 |
|
Sundhedsliv |
Urolithin A Supplement 1500mg - 30 Servings |
Simple Supplements Brand |
Free from GMOs, Dairy, Nuts, Gluten, Soy, Sugar |
1000mg |
Yes (Brown Rice Protein) |
High |
$18.69 |
|
Totaria |
Urolithin A Supplement 1000mg - 60 Servings |
Safety and Nutrition |
GMP certified |
1000mg |
Yes (NAD+, CoQ10, Resveratrol, PQQ) |
High |
$28.99 |
How Do We Choose the Best Urolithin A Supplements?
Brand Reputation
Brand reputation is crucial when choosing Urolithin A supplements, especially since this ingredient is relatively new to the market. Few brands currently produce it, with companies like Timeline, Neurogan, Pure Encapsulations, Sundhedsliv, and Totaria leading the way. After thorough research and analysis of their transparency and customer feedback, we've included these trusted brands in our list of the best options available.
In addition to transparency, there are several key factors to assess a brand's reputation and trustworthiness. These include the consistency of their product quality, customer reviews, third-party testing results, and certifications like GMP (Good Manufacturing Practice).
A reputable brand will also provide clear sourcing information, customer service responsiveness, and any trials or research supporting their claims. Brands that prioritize these aspects demonstrate a commitment to quality and consumer trust.
Urolithin A Content
The products on our list contain Urolithin A in doses ranging from 400mg to 1000mg per serving. This range is considered effective for supporting mitochondrial health and promoting healthy aging, while also minimizing the risk of side effects. By staying within this range, these supplements deliver the necessary potency without overwhelming the body, ensuring a balanced approach to health benefits.
Form and Dosage
When it comes to form and dosage, the products in our list primarily come in capsule form, which is widely preferred due to its convenience and ease of use. Capsules are also well-known for their accurate dosage and fast absorption.
Additionally, some products are available in softgel form, which not only makes them easier to swallow but also helps protect the Urolithin A from oxidation, ensuring the supplement maintains its potency and effectiveness throughout its shelf life.
Manufacturing Standards and Certifications
Manufacturing standards and certifications are critical in ensuring product quality and safety. The brands in our list adhere to strict production protocols, including cGMP (Current Good Manufacturing Practices) certification, which guarantees consistency and compliance with quality standards.
Many of these brands also hold third-party testing certifications, ensuring purity and potency. Additionally, some products are non-GMO, gluten-free, and vegan-friendly, reflecting a commitment to catering to diverse consumer needs and maintaining transparency in ingredient sourcing and manufacturing practices.
Price and Value for Money
Price and value for money are key considerations when choosing the best Urolithin A supplements. Our list features a range of options, with budget-friendly products priced between $18 and $40, and premium offerings reaching up to $100.
Pricing often reflects factors such as dosage, Urolithin A content, and production methods. To make an informed decision, it's important to compare these details carefully. Refer to our comprehensive summary table above for a detailed breakdown.
Formula
When evaluating the formula of Urolithin A supplements, it's essential to consider the combination of ingredients. Many manufacturers enhance their formulas with beneficial compounds like Trans-Resveratrol and Coenzyme Q10, which support cellular energy production and synergize with Urolithin A to boost overall effectiveness.
However, formulas should be well-balanced; products that overload ingredients at excessive levels may be misleading and compromise quality. Third-party testing and evaluation of these formulas are crucial to ensure safety and efficacy, providing consumers with confidence in their choice.
Testimonial Disclaimer
*The testimonials presented on this website are provided by individuals based on their personal experiences with our products. These testimonials represent individual opinions and experiences, which may not be typical or applicable to all users of our products. Results may vary depending on a variety of factors, including individual health, lifestyle, and adherence to product usage instructions.5 Best Urolithin A Supplements for Healthy Aging:
1. Timeline Mitopure Urolithin A 500mg - 60 Servings | $112.5
Review
Timeline Mitopure Urolithin A is a dietary supplement formulated to support healthy aging by promoting mitochondrial health, the key components of cellular energy production. It utilizes Mitopure, a proprietary form of Urolithin A, a naturally occurring metabolite derived from pomegranates. Unlike other supplements that focus on NAD+ levels or CoQ10, Mitopure is designed to support the process of mitophagy, which helps the body maintain healthy mitochondria by removing damaged ones.
This innovative formula has received significant attention, with over 1,300 reviews on Amazon, earning it the "Amazon's Choice" designation. Many users have shared positive experiences, including increased energy levels and improved overall well-being. Some individuals also report that the supplement may contribute to healthier hair.*
Pros
- Powered by Mitopure: Utilizes a unique and potent form of Urolithin A for effective mitochondrial rejuvenation.
- Scientifically Backed: Supported by research and clinical trials demonstrating its potential benefits.
- High-Quality Ingredients: Manufactured in the USA with globally sourced ingredients and third-party tested for purity and potency.
- Premium Quality: Developed by doctors and scientists with over 15 years of experience in the field of longevity.
- Comprehensive Certifications: NSF Certified for Sport, Clean Label Project Certified, Gluten-Free, and Non-GMO.
- Significant Urolithin A Content: Provides 6x more Urolithin A than a glass of pomegranate juice.
- Amazon's Choice: A highly-rated product with strong customer satisfaction.
Cons
- High Price: Considered expensive by some customers.
- Mixed Reviews: Despite high overall ratings, 14% of reviews on Amazon are 1-star, indicating a significant level of dissatisfaction among some users.
- Capsule Quality Concerns: Some customers have expressed dissatisfaction with the quality of the capsules.
- Wasteful Packaging: Concerns have been raised about the excessive packaging, particularly the glass bottle, which adds to the overall cost and environmental impact.
2. Neurogan Health Urolithin A Capsules 1000 mg - 60 Servings | $80
Review
Neurogan Health Urolithin A Capsules provide a robust 1000mg dose of Urolithin A per serving, a naturally occurring metabolite found in fruits like pomegranates. Urolithin A's bioavailability can be limited, so Neurogan’s formulation utilizes Ultra-micronization technology to enhance absorption, helping to optimize its potential benefits for cellular health. This process supports mitochondrial biogenesis, which plays a role in generating cellular energy and supporting overall vitality, particularly in muscle cells.
The capsules are designed for adults, athletes, and those with active lifestyles, with the aim of promoting muscle health and supporting overall energy levels. Many users have shared positive feedback, including reports of increased physical energy and enhanced well-being. Some individuals have noticed improvements in exercise performance, muscle, joint, and skin strength. Additionally, users have experienced better focus, mental clarity, and improved sleep quality.*
Pros
- High Potency: Provides a potent 1000mg dose of Urolithin A per serving.
- Enhanced Absorption: Utilizes Ultra-micronization technology for optimal absorption.
- Supports Mitochondrial Health: Promotes mitochondrial biogenesis, crucial for cellular energy production.
- Benefits Multiple Areas: Supports muscle health, energy levels, cognitive function, and skin health.
- Convenient Dosage: Two capsules per serving for easy integration into daily routines.
- Premium Quality: Made in the USA in a GMP-certified facility with third-party lab testing.
- Vegan and Plant-Derived: Suitable for those following plant-based diets.
- Amazon's Choice: A highly-rated product with strong customer satisfaction.
Cons
- Price: May be considered expensive by some consumers.
3. Pure Encapsulations Renual Urolithin A Supplement 460 mg - 30 Servings | $73
Review
Pure Encapsulations Renual is a dietary supplement designed to support healthy aging and cellular function through a combination of Urolithin A, Trans-Resveratrol, and Coenzyme Q10.
Renual combines Urolithin A with Trans-Resveratrol, an antioxidant with potential benefits for heart health and aging, and Coenzyme Q10, another important player in cellular energy production.
Pure Encapsulations emphasizes the use of premium ingredients sourced from trusted suppliers and manufactured using rigorous quality control procedures. Additionally, Renual is formulated to be free of common allergens like gluten, soy, and dairy, and caters to vegan and vegetarian dietary needs. The capsules are also designed for easy swallowing and the company prioritizes minimizing plastic waste in packaging.
Customer reviews on Renual are mixed. While some users haven't experienced noticeable effects, others report positive impacts on energy levels and overall well-being. However, a recurring point of concern has been the product's price, which is considered expensive by some consumers. There have also been isolated reports of issues with capsule quality, with some users encountering sticky capsules that appeared damaged.*
Pros
- Combines Urolithin A, Trans-Resveratrol, and Coenzyme Q10 for comprehensive support.
- Uses premium ingredients from trusted suppliers.
- Third-party tested for purity and potency.
- Free of common allergens and suitable for vegans and vegetarians.
- Easy-to-swallow capsules.
- Company prioritizes environmentally friendly packaging.
Cons
- Considered expensive by some users.
- Some customers have reported issues with capsule quality.
4. Sundhedsliv Urolithin A Supplement 1500MG - 30 Servings | $18.69
Review
Sundhedsliv Urolithin A Supplement is designed to support physical performance and endurance, making it an attractive option for athletes and active individuals. Each serving provides a potent dose of 1000mg of Urolithin A, a metabolite known to promote mitochondrial health.
This supplement incorporates brown rice protein, which enhances digestion and absorption, making it suitable for individuals with dietary restrictions or sensitivities. The inclusion of brown rice protein also adds a nutritional element to the formula.
Sundhedsliv emphasizes quality control, ensuring the product is free from GMOs, dairy, nuts, gluten, soy, and sugar. The formula is also vegetarian-friendly, catering to a wider range of dietary preferences.
Customer reviews on Amazon are highly positive, with 89% of ratings being 5 stars. Customers consistently praise the supplement's effectiveness in boosting energy levels and improving overall health. Many appreciate the value for money, finding it comparable to more expensive brands.*
"I like that this product comes highly recommended by functional medicine practitioners, and I notice more zip in my step, and in my conscious mind," says C. Wahl, "I have only taken it for two weeks so I expect that I will feel more as time goes on. It's worth trying. I like that I have no side effects, like nausea, when I take it. It goes down easy."*
Pros
- High potency: Provides 1000mg of Urolithin A per serving.
- Supports physical performance and endurance.
- Includes brown rice protein for enhanced digestion and absorption.
- Suitable for individuals with dietary restrictions.
- Free from GMOs, dairy, nuts, gluten, soy, and sugar.
- Vegetarian-friendly.
- High customer satisfaction with 89% 5-star ratings on Amazon.
Cons
- Limited information available on specific health benefits beyond energy and endurance.
5. Totaria Urolithin A Supplement 1000mg - 60 Servings | $28.99
Review
Totaria Urolithin A Supplement is a comprehensive formula designed to support overall health and vitality. It features a synergistic blend of 1000mg Urolithin A alongside NAD+, Coenzyme Q10, Resveratrol, and PQQ. These key ingredients work together to support mitochondrial health, a crucial factor in cellular energy production and overall well-being.
This supplement offers a range of potential benefits, including increased energy levels, improved muscle function, enhanced cognitive health, and antioxidant support. Designed for individuals seeking to maintain peak physical and cognitive performance, Totaria Urolithin A can be a valuable addition to any health-conscious lifestyle.
"I ordered these to replace another brand of the same substances. I've been taking them for a couple of weeks and, so far, I've had no negative issues. I also have more confidence in this brand, as it's GMP certified. They're a good "bang for the buck" choice," shares Squire O'Draighnean, highlighting the value and quality of the supplement.*
However, capsule size may be an issue for some users, as reported by Dave J.: "Great formula. But useless if you can't swallow it. Any nurse can tell you that round pills are hardest to swallow because round pills don't know the difference between up and down and so refuse to align with the esophagus to be swallowed. They just tumble around and get stuck."*
Pros
- High potency: Provides 1000mg of Urolithin A per serving.
- Synergistic blend: Combines Urolithin A with NAD+, Coenzyme Q10, Resveratrol, and PQQ for comprehensive support.
- Supports multiple health areas: Benefits mitochondrial health, energy levels, muscle function, cognitive health, and antioxidant defense.
- Manufactured in the United States.
- GMP certified.
- Convenient 2-month supply.
- Amazon's Choice: Indicates high customer satisfaction and quality.
Cons
- Capsule size may be an issue for some users
Frequently Asked Questions
What Does Urolithin A Do To Your Body?
Urolithin A is a naturally occurring compound produced by gut bacteria when you consume certain foods like pomegranates, walnuts, and berries. Research suggests that Urolithin A can have several beneficial effects on the body, particularly in relation to muscle health. It has been shown to stimulate mitophagy, a process that removes damaged mitochondria, which can improve muscle function in older individuals. Studies also indicate that Urolithin A may enhance muscle protein synthesis and growth. While promising, further research is needed to fully understand the mechanisms of Urolithin A and its potential for human application [1] [2].
What Are The Side Effects Of Urolithin A?
While Urolithin A is generally well-tolerated, some individuals may experience mild side effects. These can include gastrointestinal upset, such as stomach pain, bloating, gas, or diarrhea. Headaches and allergic reactions have also been reported in some cases. Although rare, Urolithin A may interact with certain medications. However, a recent systematic review found no serious adverse events directly linked to Urolithin A supplementation. Most reported side effects, including muscle aches and headaches, were mild and considered unrelated to the treatment [2].
How Much Urolithin A Should You Take?
The recommended dosage of Urolithin A, specifically Mitopure, can vary depending on individual needs and product formulation. Most studies have used doses ranging from 10mg to 1000mg daily. However, for optimal benefits in terms of mitochondrial health, muscle strength, and endurance, a dosage of 500mg to 1000mg per day is commonly suggested. Both softgels and powders are available, offering flexibility for different preferences. It's important to note that while Urolithin A is generally well-tolerated, individual responses can vary. Always consult with a healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking other 1 medications [2].
What Is The Best Source Of Urolithin A?
The richest dietary sources of Urolithin A are pomegranates, walnuts, and almonds. These foods contain compounds that your gut bacteria can convert into Urolithin A. In particular, pomegranate peel and seeds are especially rich in these compounds [3].
Is Coq10 Better Than Urolithin A?
While both CoQ10 and Urolithin A offer potential benefits for mitochondrial health, CoQ10 is often considered a more established and versatile option. With a longer history of research and a track record of supporting overall health, CoQ10 has a broader range of applications. Urolithin A, while promising, is still a relatively new compound with ongoing research.
How Long Does It Take For Urolithin A To Work?
The time it takes for Urolithin A to show benefits can vary from person to person. However, many people notice improvements in muscle endurance and energy levels within 4-8 weeks of consistent use. For more long-term benefits related to metabolic health and aging, it's recommended to continue taking Urolithin A for at least 12 weeks.
Conclusion
When selecting a Urolithin A supplement, prioritize purity, potency, and third-party testing. Consider factors such as your overall health goals, budget, and any specific dietary restrictions. By carefully evaluating options like Timeline, Neurogan Health, and Pure Encapsulations, you can find a supplement that aligns with your needs and supports optimal mitochondrial function. Remember to consult with a healthcare professional before starting any new supplement regimen.
References
- [1] Zhao, H., Song, G., Zhu, H., Qian, H., Pan, X., Song, X., Xie, Y., & Liu, C. (2023). Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects. Nutrients, 15(20), 4441–4441. https://doi.org/10.3390/nu15204441
- [2] Ajla Hodzic Kuerec, Lim, X. K., Khoo, A. L., Sandalova, E., Guan, L., Feng, L., & Maier, A. B. (2024). Targeting aging with urolithin A in humans: A systematic review. Ageing Research Reviews, 100, 102406–102406. https://doi.org/10.1016/j.arr.2024.102406
- [3] Zhao, H., Song, G., Zhu, H., Qian, H., Pan, X., Song, X., Xie, Y., & Liu, C. (2023). Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects. Nutrients, 15(20), 4441–4441. https://doi.org/10.3390/nu15204441
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