Glynac Before Bed

The Benefits of Taking GlyNAC Before Bed

GlyNAC, a combination of Glycine and NAC (N-Acetylcysteine), has become a popular supplement for those seeking benefits from sleep support to immune system enhancement. When taken before bed, GlyNAC can provide numerous significant health benefits. Why should you take GlyNAC before sleep, and what effects does it have? This article will delve into GlyNAC, how it works, and the benefits it may offer when taken before bed.

Before exploring further, please read the disclaimer located at the end of this webpage.

Key Takeaways

  • GlyNAC is a combination of Glycine and NAC, providing support for sleep, stress reduction, and immune strengthening.
  • GlyNAC helps improve sleep quality by increasing serotonin, reducing stress, and lowering body temperature.
  • GlyNAC may support cognitive function, enhancing memory and alertness for the next day.
  • By boosting glutathione, GlyNAC helps protect the body from harmful agents.

What Is GlyNAC?

Glynac is a combination of Glycine and NAC

GlyNAC is a combination of Glycine and NAC (N-Acetylcysteine), two well-known supplements with health-promoting effects. Glycine, an amino acid, reduces stress and supports sleep, while NAC is a precursor of glutathione, a key antioxidant that protects the body from free radicals and enhances the immune system. Together, they form GlyNAC, providing impressive synergistic benefits.

Is GlyNAC Good To Take Before Bed?

Taking GlyNAC before sleep has been shown to offer many health benefits, especially for those experiencing sleep issues and stress. Glycine in GlyNAC can help lower body temperature and stimulate serotonin production – a neurotransmitter linked to sleep.

More specifically, research on the effects of GlyNAC on patients with symptoms of sleep disorders concluded that: “In acute sleep disturbance, oral administration of glycine-induced non-rapid eye movement (REM) sleep and shortened NREM sleep latency with a simultaneous decrease in core temperature. Oral and intracerebroventricular injection of glycine elevated cutaneous blood flow (CBF) at the plantar surface in a dose-dependent manner, resulting in heat loss” [1].

The Benefits Of Taking GlyNAC Before Bed

Improved Sleep Quality

GlyNAC helps regulate body temperature, lowering it to support better sleep quality. Additionally, GlyNAC positively affects glutathione, which is closely related to blood circulation in the body, enhancing blood flow to the brain and protecting the nervous system during sleep [2].

Increases Serotonin Levels

Glycine is a substance that promotes the production of serotonin receptors in the brain's lobes, helping to create better serotonin in the brain [3]. Serotonin not only regulates mood but also helps the body easily fall asleep, or more precisely, has the ability to regulate sleep quality.

By: “Serotonin neurotransmission is involved in the behavioral state of animals and plays an important role in regulating behavioral states, by interacting with other brain regions that regulate circadian rhythms, sleep and waking” [4].

Therefore, taking serotonin before bed can help you feel relaxed and fall asleep more easily.

Lowers Body Temperature

As mentioned, consuming glycine as part of the GlyNAC combination may help reduce overall body temperature: “...Oral and intracerebroventricular injection of glycine elevated cutaneous blood flow (CBF) at the plantar surface in a dose-dependent manner, resulting in heat loss” [5].

Reduced Stress And Anxiety

Glynac's impact on serotonin can indirectly reduce stress and anxiety

Clinical studies on the brain demonstrate that serotonin also has a strong influence on stress and anxiety. Stress is alleviated by the release and reuptake of serotonin [6]. Therefore, GlyNAC's impact on serotonin can indirectly reduce stress and anxiety.

Boosted Immunity

Research on GlyNAC supplementation in older adults provides an overall conclusion that: “Glycine and N-acetylcysteine ​​(GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, and Mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength and cognition” [7].

Therefore, it is no exaggeration to say that GlyNAC helps significantly increase our resistance with dozens of impressive health benefits.

Enhanced Cognitive Function

Also, the same study comparing young adults aged 2-30 years with the elderly group aged 71-80 years under the influence of GlyNAC supplementation showed that: “GlyNAC supplementation for 24 weeks has a significant impact on both cognitive performance and physical function tests. GlyNAC significantly improved performance on all cognitive function assessments measured” [8].

GlyNAC: What To Know

GlyNAC Before Bed Dosage

The exact number for dosage often depends on the individual's needs. However, in the research samples shown above, the commonly used dose was 1.33 mmol/kg/day and was increased in cases where the required effects were not achieved.

However, this number is quite difficult to track because it only takes into account GlyNAC content. To make it easier, you can follow the pre-measured dosages provided by supplement manufacturers to control your dosage more easily.

Best Time To Take GlyNAC

Take GlyNAC 3-60 minutes before bed to allow time for absorption

Normally, you should use GlyNAC about 3-60 minutes before bed so that GlyNAC has enough time to absorb and produce the necessary amount of serotonin to help you regulate sleep.

GlyNAC Side Effects

Although generally safe, some may experience nausea, diarrhea, or headaches if taken improperly or interacted with other medications. Reduce dosage or consult a professional if side effects occur.

GlyNAC Drug Interactions

If taking anticoagulants or cholesterol medications, consult a healthcare professional before adding GlyNAC to avoid potential health issues.

Conclusion

In summary, taking GlyNAC before bed can offer various health benefits, from improved sleep quality to boosted immunity and cognitive function. However, pay attention to dosage, timing, and drug interactions to ensure safety. GlyNAC is an ideal choice for those seeking restful sleep every night!

References

  • [1] [5] Kawai, Nobuhiro, et al. “The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus.” Neuropsychopharmacology, vol. 40, no. 6, Dec. 2014, pp. 1405–16. https://doi.org/10.1038/npp.2014.326.
  • [2] [7] [8] ---. “Glycine and N‐acetylcysteine (GlyNAC) Supplementation in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Insulin Resistance, Endothelial Dysfunction, Genotoxicity, Muscle Strength, and Cognition: Results of a Pilot Clinical Trial.” Clinical and Translational Medicine, vol. 11, no. 3, Mar. 2021, https://doi.org/10.1002/ctm2.372.
  • [3] Lanznaster, Débora, et al. “Metabolomics as a Crucial Tool to Develop New Therapeutic Strategies for Neurodegenerative Diseases.” Metabolites, vol. 12, no. 9, Sept. 2022, p. 864. https://doi.org/10.3390/metabo12090864.
  • [4] Ursin, Reidun. “Serotonin and Sleep.” Sleep Medicine Reviews, vol. 6, no. 1, Feb. 2002, pp. 55–67. https://doi.org/10.1053/smrv.2001.0174.
  • [6] Chaouloff, Francis. “Serotonin, Stress and Corticoids.” Journal of Psychopharmacology, vol. 14, no. 2, Mar. 2000, pp. 139–51. https://doi.org/10.1177/026988110001400203.

Author

Ralph S Albert
Ralph S Albert
Ralph S. Albert is an esteemed professional with a remarkable career spanning over 15 years in the dynamic and ever-evolving realm of the food and nutrition industry. Currently, Ralph proudly serves as the Head of Research at Vinatura Supplements, a leading company in the dietary supplement industry. His work is characterized by a dedication to innovation, compliance, and the application of scientific research to create natural, yet practical solutions for consumers.
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