7 Best TMG Supplements for NAD+ Support
NAD+ is essential for maintaining cellular health and energy production. This guide will explore the 7 best TMG supplements designed to support these vital functions. With a focus on quality, affordability, and thoughtful formulations, these products will empower your journey toward a healthier and more energetic life.
Before exploring further, please read the disclaimer located at the end of this webpage.
Comparison Table of 3 Best TMG Supplements
|
Criteria |
Vinatura NMNH 1250 mg |
Life Extension TMG 1000 mg |
Vitality Pro TMG 500 mg |
|
Brand’s Insight |
Transparency and Commitment to Quality |
International Brand |
Third Party Tested Supplements Brand |
|
Quality Certification |
cGMP-certified, third-party tested |
Non GMO |
GMP-certified, third-party tested |
|
Form |
Capsules |
Capsules |
Capsules |
|
Price ($) |
$45 |
$9.75 |
$22.00 |
Additional Insights
1. Vinatura NMNH:
- Benefits: Advanced NAD+ support with a balanced mix of NMNH, Nicotinamide Riboside, and TMG.
- Standout Feature: Combines powerful anti-aging compounds for enhanced NAD+ production.
2. Life Extension TMG:
- Benefits: Cost-effective and supports cardiovascular health by maintaining homocysteine levels.
- Standout Feature: Excellent value for those focusing on heart health.
3. Vitality Pro TMG
- Benefits: Comprehensive support for methylation, brain function, liver health, and cellular protection.
- Standout Feature: Perfect for enhancing mental clarity, detoxification, and stress resilience.
How Do We Choose the Best TMG Supplements?
To choose the best TMG (Trimethylglycine) supplements, we focus on four essential factors: ingredients and origin, effectiveness, safety, and form and dosage.
Products that meet strict quality certifications and offer scientifically backed benefits are prioritized. Transparency about sourcing, safety testing, and certifications also influences our evaluation.
Brand Reputation
Vinatura’s commitment to transparency is evident through the disclosure of detailed ingredient sourcing and manufacturing standards. This level of openness reassures customers about the quality of the product and the brand’s integrity.
Choose products from reputable brands with GMP certification or third-party quality verification from organizations like NSF or USP.
Ingredients and Origin
TMG supplements should include pure trimethylglycine derived from trusted sources and free of harmful additives or allergens.
Key standards include:
- Non-GMO and gluten-free formulations.
- No artificial preservatives or unnecessary fillers.
Research indicates that effective doses range from 500-2000 mg/day, depending on individual health goals. Proper dosage ensures the product’s benefits without exceeding safe limits [1].
Choosing a supplement with clear labeling about ingredient purity and source ensures better trust and transparency.
Effectiveness
TMG supports health in multiple ways:
- Heart Health: It may help reduce homocysteine levels.
- Liver Function: Enhances methylation, critical for detoxification and metabolic processes.
- Energy and Mental Health: Provides methyl groups that contribute to cognitive function and energy production.
Scientific evidence highlights TMG’s ability to promote methylation, a key process influencing DNA repair and overall cellular health. However, individual results may vary, emphasizing the importance of consistency and correct dosage.
It also helps reduce stress, sleep, and cognitive function by supporting the production of S-adenosylmethionine (SAMe), which promotes emotional well-being and overall physiological balance.
Safety
TMG is generally safe for most individuals when taken as directed. However, potential side effects may include nausea, diarrhea, or mild stomach upset, particularly at higher doses [1].
Safety certifications to look for:
- GMP (Good Manufacturing Practice).
- Non-GMO certification.
- Third-party testing for contaminants like heavy metals.
Special populations, such as pregnant women or those with specific medical conditions, should consult a healthcare provider before use.
Form and Dosage
TMG supplements are available in three main forms:
- Capsules/ Tablets: Convenient, pre-measured, and easy to take.
- Powder: Flexible for custom dosages but requires careful preparation.
Advantages of each:
- Capsules are ideal for busy individuals who prioritize simplicity.
- Powder offers cost-effectiveness and dose customization for advanced users.
A daily dose between 500-1000 mg is often sufficient for general health, while specific health goals might require up to 20,000 mg/day.
Price and Value
The price for supplements typically ranges from $0.3 to $2 per serving, offering various options for consumers depending on their budget.
Vinatura NMNH, Nicotinamide Riboside & TMG may come at a higher price point compared to some alternatives, but the exceptional quality and high purity of their products, such as the NMNH and Nicotinamide Riboside blend, make it an excellent investment in long-term health benefits.
Testimonial Disclaimer
*The testimonials presented on this website are provided by individuals based on their personal experiences with our products. These testimonials represent individual opinions and experiences, which may not be typical or applicable to all users of our products. Results may vary depending on a variety of factors, including individual health, lifestyle, and adherence to product usage instructions.7 Best TMG Supplements for NAD+ Support:
1. Vinatura NMNH, Nicotinamide Riboside & TMG 1250 mg - 30 Servings | $42.00 | Best for NAD+ Support
This advanced supplement supports NAD+ levels, offering anti-aging benefits and promoting overall health.
Vinatura NMNH combines cutting-edge science and quality ingredients to deliver superior NAD+ support. NMNH and Nicotinamide Riboside are renowned for enhancing cellular energy and longevity, while TMG complements the formula with methylation support.
- NMNH (Dihydronicotinamide Mononucleotide) – 500 mg
- Boosts NAD+ levels more effectively than traditional NAD supplements.
- Nicotinamide Riboside – 500 mg
- Promotes healthy aging by stimulating NAD+ production.
- TMG (Trimethylglycine) – 250 mg
- It supports methylation processes that are essential for heart health and DNA repair.
Vinatura NMNH is manufactured in the USA in FDA-registered, cGMP-certified facilities. Each batch undergoes third-party testing to ensure purity, potency, and safety. The product is free from common allergens, artificial preservatives, and unnecessary fillers.
Pricing and Where to Buy
- Official Website:
- Price: $42.00 (Discounted from $45.00)
- Shipping: Free standard shipping is available. 90-day money-back guarantee.
- Amazon:
- Price: $42.00
- Shipping: Free with Prime. Flexible delivery through AutoShip options.
2. Life Extension TMG 500 mg 1000 mg - 30 Servings | $8.78
Life Extension TMG is a supplement designed to help maintain healthy homocysteine levels, supporting cardiovascular health and overall well-being. With 30 servings per bottle, this product is a natural choice for improving heart function and overall health.
Life Extension’s TMG formula features an advanced combination of ingredients, with Trimethylglycine (TMG) at its core. Additionally, the product is designed to support mitochondrial function and promote a healthy immune response, making it an ideal option for those seeking to boost their overall health.
Ingredients and Benefits:
- (TMGTrimethylglycine) (1000 mg): Supports healthy homocysteine levels, vital for heart health.
- Glycerin: Used as a stabilizer and moisture-retaining agent.
- Cellulose (capsule shell): Provides a vegetarian-friendly capsule.
- Purified Water: Ensures the product is free from impurities.
Benefits:
- Supports healthy homocysteine levels to promote cardiovascular health.
- Helps manage heart health and supports the body's natural response to stressors.
- Enhances overall health by supporting mitochondrial function.
Certified Quality:
Life Extension TMG 500 mg is manufactured in an FDA-approved facility that follows Good Manufacturing Practices (GMP). The product meets stringent quality standards to ensure purity and safety.
Price and Where to Buy:
- Official Website:
- Price: $8.78 (original price: $9.75)
- AutoShip & Save: Save up to 17% on recurring orders with flexible delivery options.
- Amazon:
- Price: $9.26 (on sale from $9.75)
- Subscribe & Save Price: $8.99 (5%-10% off)
3. THORNE Methyl-Guard Plus - 30 Servings | $57
THORNE Methyl-Guard Plus is a dietary supplement that supports healthy methylation, boosts energy production, and promotes cardiovascular and cognitive health through its potent blend of vitamins and nutrients.
THORNE Methyl-Guard Plus offers a science-backed formula with active forms of B vitamins, such as Methylcobalamin (Vitamin B12) and 5-MTHF (Folate), combined with Betaine Anhydrous. This powerful blend is ideal for individuals with MTHFR gene mutations or those seeking to enhance energy, cardiovascular health, and brain function.
Produced by Thorne, a brand trusted by over 100 professional sports teams and collaborating with Mayo Clinic, Methyl-Guard Plus is manufactured in an FDA-approved facility. This ensures the highest quality and potency for maximum effectiveness.
Price & Where to Buy:
- Official Website:
- Price: $57.00
- Subscription Discount: Save up to 20% when subscribing.
- Amazon:
- Price: $54.99
4. Parti Qlar Pure TMG 500 mg - 60 Servings | $13.99
Parti Qlar Pure TMG is a pure Trimethylglycine (TMG) supplement containing 500 mg per serving. It is designed to support cardiovascular health, improve cellular hydration, and optimize support methylation. With 60 servings per bottle, this product is vegan-friendly, non-GMO, and gluten-free.
- High Purity: Parti Qlar ensures the product contains no fillers or unnecessary additives, focusing solely on pure TMG.
- Third-Party Testing: Undergoes third-party testing for safety and effectiveness.
- Certified Manufacturing: Made in the USA, following GMP standards and FDA certifications.
- Non-GMO: Naturally sourced ingredients without genetic modifications.
- GMP Standards: Manufactured in GMP-compliant facilities, meeting FDA regulations.
- Vegan-Friendly: Suitable for vegans and free from common allergens.
Price & Where to Buy:
- Official Website: Price: $13.99
5. Pro Health TMG Pro Tablets 1000 mg - 120 Servings | $16.57
ProHealth Longevity TMG Pro Tablets deliver 1000 mg of Trimethylglycine (TMG) per tablet, a powerful supplement that supports methylation processes, promotes cardiovascular health, enhances cellular energy, and aids in liver detoxification. These vegan-friendly tablets are ideal for daily use and come in a convenient bottle of 120 servings.
- Advanced Formula: Each tablet provides 1000 mg of TMG to ensure optimal support for methylation, DNA repair, and energy production.
- Cardiovascular and Anti-Aging Benefits: Helps reduce homocysteine levels, protecting heart health and replenishing methyl reserves. Additionally, TMG supports detoxification by donating methyl groups, which are essential for healthy liver function and efficient detoxification processes, further promoting overall well-being and longevity.
- Vegan and Allergen-Free: Free from GMOs, gluten, and common allergens, making it suitable for various dietary needs.
Certified Quality
- Trusted Brand: ProHealth Longevity has earned an A+ rating from the Better Business Bureau for 33 consecutive years.
- Rigorous Testing: Manufactured under strict GMP standards and verified by third-party testing for purity and effectiveness.
- Non-GMO and Vegan: Suitable for a wide range of dietary preferences.
Price & Where to Buy:
- Official Website:
- Price: $16.57 for a one-time purchase; $11.60 with a 30% Subscribe & Save discount.
- Amazon:
- Price: $14.91 (25% off the original $19.99).
- Subscribe & Save: Additional 10%-15% discount for regular deliveries.
6. Vitality Pro TMG 500mg - 60 Servings | $22
Vitality Pro TMG 500mg provides a pure Trimethylglycine (TMG) supplement designed to support cellular health, cardiovascular function, and liver detoxification. Each capsule delivers 500mg of TMG, making it an ideal choice for optimizing methylation processes and enhancing overall wellness.
- Pure and Potent Formula: This contains 500mg of TMG in each capsule, specifically formulated to support vital cellular functions like methylation, DNA repair, and detoxification.
- Vegan-Friendly: Suitable for various dietary preferences and free from common allergens.
- Science-Backed Benefits: Known to reduce homocysteine levels, aiding cardiovascular health and energy production.
- Third-Party Tested: Independently verified for purity and effectiveness, ensuring you receive a premium-quality supplement.
- Manufactured in GMP-Certified Facilities: Ensures safety and adherence to strict production standards.
- Non-GMO and Allergen-Free: No artificial additives, fillers, or preservatives, making it safe for sensitive users.
Price & Where to Buy:
- Official Website: Price: $22 per bottle (60 servings). Subscription Discount: Save 5% ($21) with recurring delivery.
7. BrainMD Betaine TMG 1000 mg - 30 Servings | $15.50
Betaine TMG is a dietary supplement containing 1000 mg of Trimethylglycine (TMG) per serving. It supports methylation, energy production, and cellular health while promoting emotional well-being and muscle strength.
Betaine TMG is crafted for individuals seeking a reliable supplement to improve methylation, reduce stress, and support overall health. Its vegan-friendly formulation, absence of artificial additives, and support for energy and liver health make it an excellent choice.
Whether you're managing stress, improving hormonal balance, or boosting exercise performance, Betaine TMG offers well-rounded benefits backed by scientific research.
Certified Quality
- Manufactured in FDA-approved, GMP-compliant facilities.
- Free from corn, soy, gluten, artificial additives, and animal products.
- Suitable for vegan and vegetarian diets.
Price & Where to Buy:
- Official Website: $15.50 for a one-time purchase.
- Amazon: $16.95
What is the Best TMG Supplement for NAD+ Support?
Vinatura NMNH is specifically designed to enhance NAD+ regeneration in the body. By combining three powerful ingredients—NMNH, NR, and TMG.
NMNH (500 mg): NMNH is a direct precursor to NAD+, meaning it helps naturally increase NAD+ levels in your cells. It also protects against oxidative stress, a key factor in aging and fatigue. You’ll feel more energized, recover faster, and experience long-term cellular health benefits.
Nicotinamide Riboside (NR) (500 mg): NR is a highly bioavailable form of vitamin B3 that converts into NAD+ to support cellular repair and energy production. It’s also known for promoting cell longevity and may help better focus and improve stamina and youthful vitality.
TMG (Trimethylglycine) (250 mg): TMG acts as a methyl donor, aiding in methylation—a crucial process for efficient NAD+ regeneration. It also supports liver detoxification and cardiovascular health.
Real-Life Benefits of Vinatura NMNH
- Feel energized: Boost your cellular energy and reduce fatigue, helping you stay active throughout the day.
- Look youthful: Support anti-aging processes, promoting glowing skin, healthy joints, and strong tissues.
- Think clearer: Enhance your focus, memory, and overall cognitive performance.
- Stay healthier: Strengthen your cardiovascular for long-term wellness.
Real users have experienced remarkable results with Vinatura NMNH:
Frequently Asked Questions
What is TMG?
TMG (Trimethylglycine), known as betaine, is a natural compound first discovered in sugar beets. It plays a crucial role in metabolic processes by providing methyl groups essential for DNA repair, detoxification, and neurotransmitter production. TMG is also recognized for its ability to potentially reduce homocysteine levels, thereby supporting heart health. You can find TMG naturally in foods like spinach, beets, and whole grains or as dietary supplements to enhance its health benefits [1].
What are the Benefits Of TMG?
Heart Health Maintenance: TMG supports maintaining optimal levels of homocysteine in the body. Research indicates that doses of up to 4 grams daily effectively aid in this process without significantly altering triglyceride levels. Additionally, it may help sustain LDL cholesterol levels within a healthy range. Enhanced Physical Performance: TMG is known to promote strength and endurance by minimizing fatigue and facilitating creatine synthesis. A 2021 study demonstrated improvements in speed and power among individuals consuming 2 grams daily [2]. Stress Management: TMG has potential benefits in supporting the body's stress response, contributing to overall well-being and vitality. General Wellness: With antioxidant properties, TMG plays a role in promoting cellular health and supporting long-term physiological functions, including DNA maintenance [2].
What Are The Side Effects Of TMG Supplements?
TMG supplements are generally safe, but they may cause side effects such as: Digestive issues, including diarrhea, bloating, cramps, nausea, or vomiting. Rare severe effects: confusion, drowsiness, behavioral changes, seizures, or brain fluid accumulation (due to elevated methionine levels). TMG is not recommended for children or pregnant or breastfeeding women. Always consult a doctor if adverse effects occur [2]. Who Should Not Take TMG? Avoid TMG if you: Are allergic to betaine or related compounds. Are pregnant, breastfeeding, or underage due to insufficient safety data. If you have medical conditions or are on medication, consult your doctor before using it [3].
Does TMG Increase Healthy Testosterone?
In addition to enhancing exercise performance, TMG supplementation appears to support healthy testosterone levels. In a 2021 study involving soccer players, those who took TMG experienced a noticeable increase in healthy testosterone compared to the placebo group. Overall, the evidence suggests that TMG supplements can positively impact both muscle performance and healthy testosterone levels [4]. When Should You Take TMG? There is no universal guideline for timing. Many studies recommend splitting doses between morning and evening for optimal benefits. Individual schedules may vary based on specific health goals [2].
Does TMG Build Muscle?
TMG may contribute to muscle building by enhancing hydration, endurance, and protein synthesis. It also supports creatine production, which is vital for muscle recovery. While initial research shows promise, further studies are needed to confirm these benefits [1].
Conclusion
TMG is a versatile supplement offering benefits like improved heart health, athletic performance, and improved mental health. However, individual results vary, and professional guidance is essential for safe use. Always prioritize natural sources and informed supplementation.
References
- [1] Human, in. (2024, March 28). My Complete Health ND. My Complete Health ND. https://www.mycompletehealthnd.com/articles/trimethylglycine-tmg-the-role-and-benefits-in-human-health
- [2] Ajmera, R. (2021, September 20). Benefits, Side Effects, and Dosage of TMG Supplements. Healthline; Healthline Media. https://www.healthline.com/nutrition/tmg-supplement
- [3] Betaine: MedlinePlus Drug Information. (2016). Medlineplus.gov. https://medlineplus.gov/druginfo/meds/a608012.html
- [4] Stanfield, B. (2024, October 9). Why TMG (Betaine) is Exploding in Popularity. Dr Brad Stanfield. https://drstanfield.com/blogs/articles/tmg-betaine-exploding-popularity
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