Calcium AKG Benefits - Side Effects and Dosage
Calcium is a crucial mineral for optimal human health, and calcium AKG supplements could potentially bridge nutritional deficiencies. They can serve as a proactive approach for individuals dealing with specific health conditions. In this blog post, we will delve into the research concerning calcium AKG, empowering you to make well-informed choices about including this vital mineral in your diet.
Before exploring further, please read the disclaimer located at the end of this webpage.
What Is Calcium AKG?
Calcium Alpha-Ketoglutarate (Ca-AKG) is a dietary supplement that combines mineral calcium with alpha-ketoglutaric acid, an organic compound produced naturally in the body. It is also known as Calcium AKG and Calcium 2-Ketoisocaproic Acid.
Alpha-ketoglutaric acid, one of the critical components in Calcium AKG, is a participant in this metabolic pathway, crucial for energy production within cells.
How Does Calcium AKG Work?
As mentioned before, Alpha-ketoglutaric acid is an intermediate molecule in the Krebs cycle, which produces energy in the body's cells.
When consumed as a supplement, calcium AKG dissociates into calcium and alpha-ketoglutaric acid, allowing each component to have its individual effects on the body.
Calcium is an essential mineral for maintaining strong bones and teeth and for proper muscle function.
On the other hand, Alpha-ketoglutaric acid is involved in various metabolic pathways in the body. It helps convert amino acids into energy, supports liver function, and aids in detoxification. It also has antioxidant properties that protect against cell damage and promote healthy aging.
When these two components are combined, calcium AKG can offer a range of potential benefits to the body. Some of these include:
- Anti-aging Benefits: The antioxidant properties of alpha-ketoglutaric acid can help protect against oxidative stress and promote healthy aging.
- Increased Energy Production: As calcium AKG helps in the metabolism of amino acids, it can give the body more energy to perform physical activities.
- Improved Workout Performance: Due to its role in energy production and muscle function, calcium AKG may help improve athletic performance and reduce exercise-induced fatigue.
- Enhanced Bone Health: Calcium is essential for maintaining strong bones and teeth, and adding alpha-ketoglutaric acid can further promote bone density and prevent osteoporosis.
- Support for Liver Function: Alpha-ketoglutaric acid has been shown to support liver health by aiding in detoxification and promoting cellular repair.
Calcium AKG Benefits
Bone Health
Calcium is well-known for its role in maintaining strong and healthy bones. It works with other minerals to build bone strength and density, making it essential to prevent conditions such as osteoporosis.
But what makes calcium AKG stand out from other calcium supplements? Adding alpha-ketoglutaric acid can further enhance the benefits of calcium for bone health. Studies have shown that this combination can increase bone mineral density, strengthen bones, and reduce the risk of osteoporosis.
A study examining the effectiveness of calcium alpha-ketoglutaric acid (AKG-Ca) at a dosage of 6g AKG and 1.68g Ca per day concluded that AKG-Ca may offer potential benefits for postmenopausal women with osteoporosis. The study suggests that AKG-Ca can lead to favorable changes in serum CTX, although further research is required to determine its long-term efficacy [8] [9].
Calcium Longevity Benefits And Anti-Aging
Research on the effectiveness of Calcium AKG for longevity and anti-aging primarily hinges on the impact of Alpha-ketoglutarate (AKG).
Research shows that supplementation with alpha-ketoglutaric acid, one of the critical components in calcium AKG, can help improve mitochondrial function, which is responsible for cell energy production [3].
Asadi Shahmirzadi's study has shown that AKG reduces disease incidence and delays the onset of aging-related features in mice, with promising results observed when administered in midlife [1].
Research by T. NIEMIEC and colleagues, published in the Journal of Psychology and Pharmacology, also concurs with the anti-aging effects of Ca-AKG, primarily stemming from the actions of AKG. The study determined that treatment with Na-AKG significantly increased the activity of glutathione peroxidase (an antioxidant enzyme) and reduced the activity of superoxide dismutase (a byproduct of oxygen metabolism that, if left unregulated, can cause cellular damage) [2].
Support Gastrointestinal and Gut Health Overall
Alpha-ketoglutaric acid has been shown to have prebiotic properties, meaning it can promote the growth of beneficial bacteria in the gut [4]. This can improve digestion, nutrient absorption, and a stronger immune system.
An evaluation of alpha-ketoglutaric acid's potential applications indicates that AKG can effectively reduce oxidative stress and prevent gastrointestinal diseases in both animals and humans [5].
Furthermore, a study examined the effects of supplementing with β-Hydroxy-β-Methylbutyrate and/or Alpha-Ketoglutaric Acid prior to birth on intestinal development and maturation, demonstrating favorable outcomes for gut health [6]. Specifically, AKG is known to influence absorption by modifying intestinal cell morphology and absorption surface, particularly in the colon.
Another review also mentioned that AKG contributes to maintaining the integrity of the gut barrier, enhancing immune cells and neutrophil activities, in addition to its disease prevention and anti-aging effects [7].
Beneficial For Kidney Health
Calcium AKG has been found to have protective effects on the kidneys by promoting healthy blood flow and supporting proper kidney function. It works by enhancing energy production in the cells of the kidneys, which helps them maintain their structural integrity and perform their functions effectively.
Calcium AKG has been found to impact kidney health positively. A study conducted by A.P. HARRISON and colleagues concluded that AKG serves as an exclusive energy source for the kidneys, resulting in improved nephrin function, enhanced nitrogen metabolism, and more efficient excretion processes [12].
Another study [14] demonstrated that AKG regulates kidney function through the biotransformation axis. Furthermore, chemical properties like acid-base balance and ion transport also contribute to the internal balance within the kidney.
Moreover, research [10] supports the notion that AKG may help maintain normal kidney function, promote faster recovery, and yield favorable outcomes in patients with chronic kidney disease.
Other Potential Calcium AKG Health Benefits
- Calcium AKG Health Benefits
- Regulates Energy and Metabolism
- Promotes Healthy Glutamine Levels
- Detoxifies Body
- Healthy Weight Loss and Management
- Promotes Collagen Synthesis
- Promotes the Proliferation of Stem Cells
Calcium AKG Side Effects
A study conducted by Bibek and colleagues investigated the potential health benefits of dietary supplementation with Alpha-Ketoglutarate (AKG) in humans. The study found that AKG is considered safe for consumption at doses up to 6g per day for a period of 6 months [10].
On the other hand, some studies suggest that AKG is generally safe and does not cause significant side effects. For instance, a study titled "Alpha-ketoglutarate supplementation and Biological age in middle-aged adults (ABLE) - intervention study protocol" indicates that Calcium Alpha-Ketoglutarate (Ca-AKG) is expected to have no adverse effects and is considered safe for consumption [11].
Furthermore, a review focusing on the effectiveness of AKG for kidney diseases also acknowledges that AKG is safe and does not pose any significant side effects.
Recommended Calcium AKG Dosage
Based on the existing research, there is no established recommended dosage of calcium AKG. However, studies have suggested a range of 2-6g per day as a safe and effective dosage for adults [9][10].
However, proper calcium AKG dosage may also depend on individual factors such as age, weight, and overall health for the maximum Calcium AKG benefits. Therefore, it is recommended to consult with a healthcare professional before taking Calcium AKG.
Who Should and Shouldn't Take Calcium Alpha-Ketoglutarate?
Calcium AKG is generally considered safe for healthy adults. However, individuals with underlying health conditions or those taking certain medications should consult with a healthcare professional before taking calcium AKG. This includes individuals with kidney disorders and those who are pregnant or breastfeeding [11].
Additionally, it is recommended to avoid large doses of calcium AKG in combination with Malate, as this may lead to adverse effects, as discussed previously.
How To Take Calcium AKG Supplement?
Calcium AKG supplements are available in various forms, including capsules and powders. The recommended dosage may vary depending on the form of supplement chosen. Always follow the manufacturer's instructions and consult with a healthcare professional before starting any supplement regimen.
Furthermore, it is suggested to take calcium AKG with food for better absorption and reduced risk of gastrointestinal side effects. Additionally, it's essential to maintain a balanced and varied diet while incorporating calcium AKG supplements for the optimized result.
Frequently Asked Questions
Is Alpha-Ketoglutarate Obtainable from Dietary Sources?
Alpha-ketoglutarate is primarily produced within our bodies and not typically obtained from dietary sources. However, it can be found in small amounts in certain foods like poultry, spinach, and broccoli. A more concentrated intake often requires supplementation.
How to Determine the Efficacy of Calcium AKG?
The efficacy of Calcium AKG can be determined through individual physiological responses and consultations with healthcare professionals. Notable improvements in energy levels, bone health, workout performance, and general wellbeing may signify its effectiveness. However, regular medical check-ups and blood tests provide more reliable and personalized assessments.
What Sets Calcium AKG Apart from AKG?
Calcium AKG differs from AKG due to the addition of calcium, a mineral essential for bone health and various metabolic functions. This combination results in a supplement with both the benefits of AKG and the essential characteristics of calcium, offering enhanced support for bone health, energy production, and anti-aging processes.
What Is The Difference Between Calcium AKG vs Arginine AKG?
Calcium AKG and Arginine AKG differ primarily based on their additional components. While both supplements contain alpha-ketoglutarate, Calcium AKG includes calcium, which is beneficial for bone health, whereas Arginine AKG is bonded with arginine, an amino acid that aids in muscle growth and nitric oxide production.
Conclusion
In conclusion, calcium AKG benefits are ranging from bone health, anti-aging to gastrointestinal health, and overall well-being. Its unique combination of alpha-ketoglutarate and calcium makes it a unique and effective supplement for promoting longevity and supporting various bodily functions.
References
- [1] W. Rhoads, Timothy. “Alpha-Ketoglutarate, the Metabolite That Regulates Aging in Mice.” Cell Metabolism, vol. 32, 2020.
- [2] Niemiec. (2017). Alpha-ketoglutarate stabilizes redox homeostasis and improves arterial elasticity in aged mice. Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, 62(1). https://pubmed.ncbi.nlm.nih.gov/21451208/
- [3] Xiao, D., Zeng, L., Yao, K., Kong, X., Wu, G., & Yin, Y. (2016). The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications. Amino Acids, 48(9), 2067–2080. https://doi.org/10.1007/s00726-016-2254-8
- [4] Yaman, T., & Harvey, J. N. (2021). Computational Analysis of a Prebiotic Amino Acid Synthesis with Reference to Extant Codon–Amino Acid Relationships. Life, 11(12), 1343–1343. https://doi.org/10.3390/life11121343
- [5] Meng, X., Liu, H., Peng, L., He, W., & Li, S. (2022). Potential clinical applications of alpha‑ketoglutaric acid in diseases (Review). Molecular Medicine Reports, 25(5). https://doi.org/10.3892/mmr.2022.12667
- [6] Dobrowolski, P., Siemowit Muszyński, Donaldson, J., Jakubczak, A., Andrzej Żmuda, Iwona Taszkun, Rycerz, K., Mielnik−Błaszczak, M., Kuc, D., & Tomaszewska, E. (2021). The Effects of Prenatal Supplementation with β-Hydroxy-β-Methylbutyrate and/or Alpha-Ketoglutaric Acid on the Development and Maturation of Mink Intestines Are Dependent on the Number of Pregnancies and the Sex of the Offspring. Animals, 11(5), 1468–1468. https://doi.org/10.3390/ani11051468
- [7] Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y., & Li, D. (2016). Alpha-Ketoglutarate: Physiological Functions and Applications. Biomolecules & Therapeutics, 24(1), 1–8. https://doi.org/10.4062/biomolther.2015.078
- [8] Alpha-Ketoglutarate Decreases Serum Levels of C-terminal Cross-Linking Telopeptide of Type I Collagen (CTX) in Postmenopausal Women with Osteopenia: Six-Month Study. (2013). International Journal for Vitamin and Nutrition Research. https://econtent.hogrefe.com/doi/abs/10.1024/0300-9831.77.2.89
- [9] Tomaszewska, E., Sylwester Świątkiewicz, Arczewska-Włosek, A., Wojtysiak, D., Dobrowolski, P., Piotr Domaradzki, Izabela Świetlicka, Donaldson, J., Hułas-Stasiak, M., & Siemowit Muszyński. (2020). Alpha-Ketoglutarate: An Effective Feed Supplement in Improving Bone Metabolism and Muscle Quality of Laying Hens: A Preliminary Study. Animals, 10(12), 2420–2420. https://doi.org/10.3390/ani10122420
- [10] Bibek Gyanwali, Zi Xiang Lim, Soh, J., Lim, C., Guan, S.-U., Goh, J., Maier, A. B., & Kennedy, B. K. (2022). Alpha-Ketoglutarate dietary supplementation to improve health in humans. Trends in Endocrinology and Metabolism, 33(2), 136–146. https://doi.org/10.1016/j.tem.2021.11.003
- [11] Sandalova, E., Goh, J., Zi Xiang Lim, Lim, Z., Diogo Barardo, Rajkumar Dorajoo, Kennedy, B. K., & Maier, A. B. (2023). Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol. GeroScience, 45(5), 2897–2907. https://doi.org/10.1007/s11357-023-00813-6
- [12] 0808_S1_article_04. (2023). Krakow.pl. https://www.jpp.krakow.pl/journal/archive/08_08_s1/articles/04_article.html
- [13] Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond. (2022). Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. https://doi.org/10.2147//DMSO.S369090
Author
Product Disclaimer
The dietary supplement products mentioned on this website are formulated based on scientific research and adhere to FDA guidelines for dietary supplements. However, the content of the articles has not been evaluated by the Food and Drug Administration (FDA) and is not intended to promote or endorse any specific product. Any products sold on this website are not intended to diagnose, treat, cure, or prevent any disease.
Opinions and Endorsements
Any claims, statements, or opinions expressed in the articles are those of the author(s) and do not necessarily reflect the views or opinions of the manufacturers of the dietary supplement products. The products sold on this website are separate from the content of the articles and are not directly endorsed or associated with the information presented here.
Liability Disclaimer
The author(s) of the articles, website, and manufacturers of the dietary supplement products do not assume any liability for any potential consequences arising from the use of the information provided in the articles. It is recommended that individuals consult with a qualified healthcare professional before making any dietary or lifestyle changes, including the use of dietary supplements.
Product Usage
Please refer to the product labels and packaging for specific usage instructions and guidelines for the dietary supplement products sold on this website.
Customer Support
For any concerns or questions regarding the dietary supplement products, please contact our customer support team, who will be more than happy to assist you.
Leave a Comment
Be the first to comment.
What do you think?