8 Lactobacillus Salivarius Benefits & Side Effects And Dosage

‌Lactobacillus salivarius is a probiotic strain known for supporting oral health, digestion, and boosts immune function. Additionally, this probiotic helps reduce harmful bacteria in the mouth, improving dental health, and preventing infections. Discover the key advantages of incorporating Lactobacillus salivarius into your daily routine.

What Is Lactobacillus Salivarius?

Lactobacillus salivarius is a beneficial bacterium from the Lactobacillus genus. This anaerobic, Gram-positive bacterium is mainly found in the mouth and gastrointestinal tract, but it is also present in the colon, small intestines, and vagina.

L. salivarius helps maintain a healthy microbial balance by producing organic acids like lactic and acetic acids, as well as antimicrobial substances such as hydrogen peroxide. These compounds work to inhibit harmful pathogens and support overall health.

You can get L. salivarius from dietary sources such as yogurt, bananas, and artichokes, or through dietary supplements. This makes it a versatile option for enhancing your health regimen.

Other Lactobacillus strains you can explore:

• Lactobacillus Acidophilus
• Lactobacillus Gasseri
• Lactobacillus Plantarum
• Lactobacillus Reuteri
• Lactobacillus Rhamnosus

Lactobacillus Salivarius Benefits

Oral Health

Lactobacillus salivarius offers multiple benefits for oral hygiene. This probiotic produces bacteriocin, a natural antimicrobial substance that defends against harmful pathogens like Listeria monocytogenes, a bacterium linked to gum disease. It also helps reduce gum plaque, which is a major cause of cavities [22].

Studies show that L. salivarius is particularly helpful for smokers, improving gum health and reducing bleeding, which tends to be worse in smokers [22].

However, some research suggests that under certain conditions, L. salivarius may promote bacterial attachment to teeth, potentially increasing the risk of cavities [23]. More studies are needed to understand this possible risk fully.

Halitosis

Halitosis, or bad breath, affects nearly half of adults worldwide. It is usually caused by an overgrowth of harmful bacteria in the mouth. Lactobacillus salivarius helps control this by limiting the growth of bacteria responsible for bad odor.

In an open-label study with 20 participants, taking L. salivarius WB21 for four weeks showed significant improvement in symptoms of bad breath. Participants also reported less gum bleeding, which is often linked to poor oral hygiene [11]. While the probiotic improved breath quality, some users experienced mild side effects like headaches and tongue discomfort [12]. However, these effects were temporary and disappeared after treatment ended.

Asthma

Research shows that taking Lactobacillus salivarius may help improve asthma symptoms by reducing inflammation and supporting the immune system.

In studies with mice, L. salivarius was found to lower allergic reactions in the airways and ease symptoms like airway tightness and inflammation, both of which are common in asthma. These findings suggest that L. salivarius could help reduce the frequency and severity of asthma attacks.

A 2015 study involving adults aged 20-35 with asthma showed that L. salivarius reduced levels of certain inflammatory proteins that contribute to asthma. By lowering these proteins and balancing the immune system, it helped patients experience fewer asthma flare-ups and better overall control of their symptoms.

Another trial with 422 children with asthma found that using a combination of Ligilactobacillus salivarius LS01 and Bifidobacterium breve B632, along with regular asthma medication, reduced asthma attacks by one-third after 8 weeks [3].

Gut Health

Lactobacillus salivarius supports gut health by preventing digestive issues like irritable bowel syndrome. It produces natural antibiotics and lactic acid, which help inhibit harmful bacteria while maintaining beneficial bacteria. It also aids in protein digestion and helps repair inflamed tissue in conditions like colitis.

Studies show that L. salivarius can restore gut microbial balance, enhance mucosal antibacterial proteins, and reduce endotoxin levels in diabetes [25].

Cancer

Numerous studies have explored how Lactobacillus salivarius might help prevent colorectal, colon, and oral cancers.

In one study, mice given a daily dose of 50 CFU/kg of Lactobacillus salivarius saw a significant decrease in cancer incidence, from 87.5% to 25% [4]. Another study indicated that Lactobacillus salivarius could inhibit colorectal cancer by suppressing the AKT signaling pathway [5].

The effectiveness of Lactobacillus salivarius REN in oral cancer has also been researched. Mice that received a daily high dose of 50 billion CFU/kg showed a notable 65% reduction in oral cancer incidence [6].

It is important to understand that Lactobacillus salivarius is used as a supportive measure rather than a treatment. Most research so far has been conducted on animals, and more studies are needed to confirm these findings in humans.

Atopic Dermatitis

A placebo-controlled study examined the effects of the probiotic Lactobacillus salivarius LS01 (DSM 22775) on 38 adults with atopic dermatitis. Participants took either probiotics or placebos for 16 weeks, with a dose of 1 billion CFU twice a day.

The results indicated that this probiotic strain may help regulate the immune system, specifically by influencing the balance of Th1 and Th2 cytokines. This makes it a promising addition to standard treatments for AD in adults [8].

In another study, 43 children with atopic dermatitis were given L. salivarius LS01 (DSM 22775) in freeze-dried form, with a dose of 2 sachets per day, each containing 1 billion CFU. After 20 weeks, the children showed significant improvements in their condition [9].

Pylori Infection

Lactobacillus salivarius is not only being explored for gastrointestinal disorders but also for its potential effects on H. pylori infection. H. pylori is a common bacterium linked to digestive problems like gastritis and ulcers.

Research suggests that L. salivarius may help combat H. pylori by producing substances such as bacteriocins and lactic acid. These substances make it difficult for H. pylori to grow [13].

A study by Yuji Aiba and colleagues used laboratory cultures and a special mouse model infected with H. pylori. The results showed that L. salivarius produced high levels of lactic acid, which successfully inhibited H. pylori growth and reduced inflammation [13].

Another study examined how different strains of Lactobacillus salivarius and other lactobacilli affected H. pylori. It found that 9 out of 28 strains of L. salivarius and 3 out of 12 other Lactobacillus species were effective in inhibiting H. pylori growth [14].

Mastitis

Many studies suggest that different strains of probiotics, including L. salivarius PS2, L. salivarius CECT5713, and L. fermentum CECT5716, have shown encouraging results in clinical trials for preventing and treating mastitis.

Recent research has investigated the effectiveness of Lactobacillus salivarius PS2 in preventing mastitis in women with a history of post-pregnancy infections. The results showed that taking L. salivarius PS2 during late pregnancy can help prevent infectious mastitis in women at risk [16].

In another study, 20 women with staphylococcal mastitis were treated with 1 billion CFU of Lactobacillus salivarius CECT5713 and Lactobacillus gasseri CECT5714 for four weeks. The treatment showed promising results [17].

Additionally, a study involving 352 women with infectious mastitis found that two probiotic strains, L. fermentum CECT5716 and L. salivarius CECT5713, were effective in improving their condition [18].

How To Take Lactobacillus Salivarius Effectively?

Lactobacillus salivarius comes in several forms, including capsules, powders, and liquids. When choosing a product, it’s important to read the label carefully and follow the recommended dosage instructions.

Typically, Lactobacillus salivarius supplements are taken once or twice daily, with or without meals. The exact dosage may vary depending on the product and individual needs. Since probiotics are not regulated by the FDA, it is crucial to select a reputable brand from a reliable source.

This probiotic strain is also naturally found in fermented foods like yogurt, sauerkraut, and kefir. Incorporating these foods into your diet can be a natural way to obtain Lactobacillus salivarius.

Additionally, Lactobacillus salivarius is present in some oral health products, such as mouthwashes and toothpastes. These products aim to enhance oral health by introducing beneficial bacteria into the mouth.

While Lactobacillus salivarius may offer various health benefits, more research is needed to fully understand its effects, benefits, and proper usage.

Lactobacillus Salivarius Side Effects and Dosage

For adults, the Lactobacillus salivarius daily dosage ranges from 1 to 10 billion CFU (colony-forming units) to minimize the risk of side effects. The recommended dosage of Lactobacillus salivarius can vary depending on the specific product and its intended use.

Possible Side Effects:

• Mild gas
• Bloating

If these symptoms persist or become severe, it is advisable to stop using the product and consult a healthcare professional.

Important Considerations:

• Individuals with weakened immune systems or chronic health conditions should consult a healthcare provider before starting Lactobacillus salivarius.
• Pregnant or breastfeeding women should be cautious, as there is limited research on the safety of this probiotic for these groups.
• Ensure the quality and safety of Lactobacillus salivarius supplements by purchasing them from reputable sources.

Although Lactobacillus salivarius is generally safe for most people, it is always wise to seek medical advice if you have any concerns.

Conclusion

Lactobacillus salivarius is a promising probiotic strain that addresses health concerns. Extensive studies show its therapeutic effects, including support for maternal health, liver function, and oral well-being.

While more research is needed for a complete understanding of Lactobacillus salivarius side effects and benefits, incorporating Lactobacillus salivarius into a healthy lifestyle offers numerous benefits.

With its wide availability in various forms, integrating this probiotic strain into your wellness routine is a simple and practical choice.