TMG And NMN: Perfect Combination For Longer Life
Aging is a natural process that affects everyone. Most older adults suffer from health-related problems such as cognitive decline, chronic diseases, and reduced quality of life. Fortunately, studies have shown that certain nutrients can help promote healthy aging and improve longevity. Two of them are TMG and NMN. In this article, let's learn what TMG and NMN are and the benefits they bring to humans' aging process.
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Key Takeaways
- TMG and NMN are two powerful supplements that can significantly enhance human health and longevity.
- TMG is a source of methyl which helps support various functions of the body, including cellular energy production and detoxification.
- NMN is a precursor to NAD+, a coenzyme needed for DNA repair.
- Together, TMG and NMN may promote anti-aging, improve cognitive function, and enhance overall health.
What Is TMG and its benefits?
Trimethylamine Glycine (TMG), also known as Betaine, is a natural compound found in a variety of foods, including beets, spinach, and wheat germ,...[1]
TMG provides methyl groups to various molecules in the body. These methyl groups play an important role in various biological processes, especially methylation, which helps maintain cellular health, liver function, and the cardiovascular system. In addition, the benefits of TMG for human health can be listed as:
- Reduce Homocysteine Levels and Protect the Heart: Homocysteine is an amino acid that increases the risk of cardiovascular disease. When Homocysteine accumulates in the body, it can damage blood vessels, increasing the risk of atherosclerosis, stroke, and other cardiovascular diseases. Research has shown that TMG when supplemented with folate, vitamins B6 and B12 helps optimize the effectiveness of reducing Homocysteine [2].
- Supports liver function: TMG supports the conversion of Choline into Phosphatidylcholine, an important component of cell membranes, which helps improve liver function and reduce fatty liver. Research shows that TMG supplementation helps reduce fat accumulation in the liver by stimulating lipid metabolism and reducing oxidative stress [3].
What Is NMN And Its Benefits?
Nicotinamide Mononucleotide (NMN) is an important intermediate in the synthesis of NAD+, a molecule that plays a key role in the biochemical processes that provide energy to cells and maintain overall health [4].
However, NAD+ levels decrease with age, which is associated with aging and the development of many chronic diseases. NMN has the ability to restore NAD+ levels in the body, thereby improving health and prolonging life. The benefits of NMN include:
- Improves cardiovascular health: NMN has been shown to restore NAD+ levels and improve cardiovascular function. NMN supplementation improves blood vessel function and arterial flexibility. This helps reduce arteriosclerosis and other age-related cardiovascular problems [5].
- Enhanced brain function and neuroprotection: NMN can protect and improve brain function thanks to its ability to restore NAD+ levels in neurons. A 2003 study found that restoring NAD+ levels with NMN can help reduce symptoms of Alzheimer’s disease, by reducing amyloid plaque formation and enhancing mitochondrial function in neurons [6].
TMG And NMN: What Can It Do To Promote Anti-Aging?
Aging is a complex process involving a decline in cellular function, DNA damage, decreased cellular energy, and oxidative stress. TMG and NMN are two compounds that have been studied for their potential to help reduce aging and extend the human lifespan.
As we age, DNA methylation in the body declines, leading to an increased risk of DNA damage and the development of age-related diseases, including cancer and neurodegeneration.
TMG helps support methylation and protects DNA from damage. TMG supplementation reduces the risk of cell damage and prolongs life. In addition, TMG significantly reduces Homocysteine levels, reducing the risk of cardiovascular disease, a major cause of death in the elderly [2].
Meanwhile, NMN enhances the activity of sirtuins, important enzymes that help regulate lifespan and protect cells from DNA damage and other aging agents. In addition, NMN helps maintain energy levels and enhance muscle function, especially in older adults. NMN can improve muscle endurance and mobility, reducing muscle function decline due to aging [5].
How Can TMG and NMN Be Supplemented?
Supplementing TMG and NMN are popular methods today to improve health, fight aging, and improve cell function. You can supplement TMG and NMN through:
- Foods in daily meals: TMG and NMN are present in many natural foods, especially radishes, cabbage, spinach, broccoli, and cereals.
- Dietary supplements: TMG and NMN supplements are now extracted in tablet and powder form, which is convenient to use. However, it is important to consult a medical professional to determine your appropriate dosage to ensure health and safety.
Recommended Dosage For TMG And NMN
The recommended dosage for TMG and NMN is no more than 1000mg per day. The use of any TMG and NMN supplements should be through the advice of medical professionals to ensure your health safety and improve the best anti-aging effects.
What Are The Side Effects Of Using TMG And NMN?
Like any other supplement, the use of TMG and NMN can also come with some potential side effects. Here are the details of the side effects that can occur when supplementing TMG and NMN:
- Gastrointestinal upset: At high doses, TMG and NMN may cause gastrointestinal symptoms such as nausea, stomach upset, or diarrhea.
- Headache, dizziness: Some people may experience headaches and dizziness when taking TMG and NMN supplements, especially during the first few doses. These symptoms may subside as the body gets used to the supplement.
- Sleep disturbances: Supplementing with TMG and NMN may cause some people to have difficulty sleeping at night. This is because they affect the body’s energy levels. To avoid this, you can supplement with TMG and NMN in the morning instead of the evening.
Conclusion
TMG and NMN are two compounds with great potential in maintaining health and fighting the aging process. Combining the use of these two compounds can help optimize the methylation process, increase NAD+ levels, and improve cell function, thereby supporting the reduction of aging and improving overall health. Hopefully, this article has provided you with useful information about TMG and NMN, and how to supplement them into the body.
References
- [1] Arenas-Jal, M., Suñé-Negre, J. M., & García-Montoya, E. (2020). Therapeutic potential of nicotinamide adenine dinucleotide (NAD). European Journal of Pharmacology, 879, 173158. https://doi.org/10.1016/j.ejphar.2020.173158
- [2] Su-Ju Lin, Leonard Guarente. (2003). Nicotinamide adenine dinucleotide is a metabolic regulator of transcription, longevity, and disease. Current Opinion in Cell Biology, Volume 15, Issue 2, Pages 241-246, ISSN 0955-0674. https://doi.org/10.1016/S0955-0674(03)00006-1
- [3] Wang, Y.-J., Paneni, F., Stein, S., & Matter, C. M. (2021). Modulating Sirtuin Biology and Nicotinamide Adenine Diphosphate Metabolism in Cardiovascular Disease—From Bench to Bedside. Frontiers in Physiology, 12. https://doi.org/10.3389/fphys.2021.755060
- [4] Lawrence Wilson. (2022). TRIMETHYLGLYCINE OR TMG. Drlwilson.com. http://drlwilson.com/ARTICLES/TRIMTHYLGLYCINE.htm
- [5] Flax, J., Wilkins, H. M., Miller, R., Griffith, S., Cork, G. K., Qiang, A., Thompson, J., Swerdlow, R. H., & Slawson, C. (2020). OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer’s Disease Cytoplasmic Hybrids. Journal of Alzheimer’s Disease, 78(4), 1743–1753. https://doi.org/10.3233/jad-200996
- [6] Richard C Winneker, Daniel Bitran, Zhiming Zhang. (2003). The preclinical biology of a new potent and selective progestin: trimegestone. Steroids, Volume 68, Issues 10–13. Pages 915-920. ISSN 0039-128X. https://doi.org/10.1016/S0039-128X(03)00142-9.
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