8 Best Akkermansia Supplements for Gut Health

Akkermansia muciniphila, a beneficial gut bacteria, has gained significant attention in recent years for its potential role in maintaining gut health. As interest in gut health continues to soar, numerous companies have developed supplements featuring Akkermansia, such as those from Toniiq, Pendulum, Double Wood, Codeage, and SuperSmart. This article will delve into the top-rated Akkermansia supplements currently available on the market.

Comparison Table of 8 Best Akkermansia Supplements

How Do We Choose the Best Akkermansia Supplements?

Brand Reputation

To choose a trusted and quality brand, we rely on a combination of industry knowledge, online research, and customer feedback. Products are selected from trusted brands with strong reputations on platforms like Amazon and other online stores. Key evaluation criteria include manufacturing transparency, customer reviews, and adherence to quality standards. Notable brands featured in our list include Double Wood, Toniiq, Codeage, and Pendulum, known for their commitment to quality and efficacy.

Akkermansia Content

We focus on supplements with clearly stated concentrations of Akkermansia muciniphila, providing transparency regarding product composition. Concentrations typically range from 100 million AFU to 3 billion AFU. Each product is reviewed for its formulation details, including strain type and overall quality.

Form and Dosage

Capsules are often preferred for their ease of use and convenience. Available dosage options vary, ranging from 100 million to 30 billion AFU per serving. This variety allows consumers to choose products aligned with their preferences. All products reviewed include detailed information to guide users in making informed decisions about their supplement choices.

Manufacturing Standards and Certifications

When selecting the best Akkermansia probiotic, it's crucial to choose a product from a reputable manufacturer. Look for brands that have a  track record in the industry and adhere to Good Manufacturing Practices (GMP) standards. Third-party certifications, such as those from NSF International or USP, can provide additional assurance of quality and purity.

Price and Value for Money

There is a wide range of options to suit different budgets. Prices typically start at $14 for affordable choices and exceed $60 for premium options. Cost is influenced by factors such as Akkermansia content, number of servings, manufacturing techniques, and brand reputation. Our focus is on identifying products that deliver excellent value without compromising quality or efficacy.

8 Best Akkermansia Supplements for Gut Health:

1. Pendulum Akkermansia Probiotic with Prebiotic Fiber 100 million AFU - 30 Servings | $89

Review

Pendulum Akkermansia Probiotic contains 100 million AFU of the proprietary Akkermansia muciniphila strain, a unique probiotic known for its ability to enhance gut health. This keystone strain naturally occurs in the intestines and works by restoring, protecting, and strengthening the gut lining, which is essential for overall digestive health. Additionally, the product includes chicory inulin, a prebiotic fiber that supports the growth of beneficial bacteria in the gut.

The capsules are plant-based and acid-resistant, designed for delayed release to ensure the strain reaches the gut where it can be most effective. It is third-party tested, manufactured in a cGMP-certified facility, and is GRAS-certified. Many users, for example World Traveler on Amazon, have shared positive feedback, reporting benefits such as improved gut health, increased energy, and a stronger digestive lining. Despite its effectiveness, some users find it pricey, and there are mixed reviews about potential stomach discomfort.*

Pros

• Contains a patented Akkermansia muciniphila strain for gut health.

• Prebiotic chicory inulin to support beneficial bacteria.

• Delayed-release capsules for enhanced efficacy.

• Third-party tested and cGMP certified.

• GRAS-certified, ensuring safety.

• Popular among customers for improving energy and gut health.

Cons

• Higher price point may be a concern for some users.

• Mixed feedback on whether it causes stomach discomfort.

• Amazon rating is 4.3 out of 5, leaving room for improvement.

2. Double Wood Akkermansia Probiotic and Postbiotic 5 Billion TFU - 60 Servings | $14.95

Review

This supplement delivers 50mg of Akkermansia muciniphila per serving, equivalent to a daily dose of 5 billion TFU per serving (50 billion CFU per gram). Akkermansia muciniphila is a widely studied strain associated with supporting a balanced gut environment. The product undergoes third-party testing to verify its quality and ensure that it meets potency standards upon consumption.

This supplement is manufactured in the USA from globally sourced ingredients and is both non-GMO and gluten-free, making it suitable for a variety of dietary preferences. Customers have praised Double Wood for its high-quality products, with many seeing positive effects on digestion and overall well-being. For example, AlexaG rated this product 5 out of 5 stars and reviewed that “I ordered this Akkermansia after reading about it in some studies. So far, so good. Double woods is one of my go-to brands for other supplements we regularly order, so I was happy to find it available from this brand.”* However, as with any supplement, results may vary, and some users may not experience immediate benefits.

Pros

• 50mg of Akkermansia muciniphila per serving.

• Supports increased GLP-1 levels for metabolic health.

• Third-party tested for potency and effectiveness.

• Manufactured in the USA with globally sourced ingredients.

• Non-GMO and gluten-free.

• One-month supply per bottle (60 capsules).

Cons

• Some users may not experience immediate effects.

• May be considered slightly pricey compared to other probiotics.

• Limited availability of information on long-term benefits.

3. SuperSmart - Akkermansia Muciniphila Postbiotic 1 Billion Non-Living Cells per Day - 60 Servings | $46.83

Review

Supersmart's Akkermansia Muciniphila Postbiotic supplement offers 1 billion non-living cells per serving, delivering maximum strength for digestive and gut health. This supplement is formulated to support the gut lining by enhancing, restoring, and strengthening it. Unlike traditional probiotics, Akkermansia muciniphila is a postbiotic, making it a more stable and effective alternative, as it does not require live bacteria to be effective. It is designed to be highly resistant to heat and oxygen, which ensures that it remains potent during encapsulation.

The product is non-GMO, gluten-free, soy-free, and vegan, making it suitable for a variety of dietary preferences. Many customers, including Jamie Matthews from the United States, have praised the supplement for its easy digestion and effectiveness in improving gut health. While some view Akkermansia as a recent trend in gut health, its potential to enhance digestive health is well-received, and it provides significant value for those seeking digestive support.*

Pros

• 1 billion non-living cells per day for maximum strength.

• Supports gut lining health by restoring and strengthening it.

• Non-GMO, gluten-free, soy-free, and vegan formula.

• Delayed-release capsules for optimal digestion.

• 60-day supply for extended use.

• Suitable for both men and women.

Cons

• Product contains non-living cells, which may not appeal to those seeking probiotics with live bacteria.

• Considered a relatively new addition to gut health supplements, with mixed opinions on long-term effectiveness.

• Slightly higher priced compared to other gut health supplements.

4. Nature’s Nutrition Akkermansia Probiotic, Inulin Prebiotic Fiber, GLP-1 Probiotic 2 Billion AFU - 30 Servings | $30.72

Review

Nature’s Nutrition Akkermansia Probiotic is a carefully crafted supplement designed to support digestive wellness for both men and women. It combines Akkermansia Muciniphila, a key probiotic known for its role in gut health, with Prebiotic Inulin Fiber, creating an ideal environment for beneficial bacteria to thrive. This unique blend aims to enhance the balance of the digestive system, supporting gut health and overall wellness.

With 2 billion AFUs (Active Fluorescent Units) per serving, this probiotic delivers a potent dose to promote gut health. The formula is non-GMO, lab-tested, and manufactured in compliance with cGMP guidelines. It is also free from gluten and other common allergens, ensuring it is suitable for a variety of dietary preferences. Many users, including Missy P, have found it easy to swallow with no aftertaste, making it a convenient addition to their daily routine.*

Pros

• Contains 2 billion AFUs per capsule for effective gut support.

• Combines Akkermansia Muciniphila and Prebiotic Inulin Fiber for enhanced digestive health.

• Non-GMO, gluten-free, and lab-tested formula.

• Manufactured in the USA following cGMP guidelines.

• Suitable for both men and women.

• No aftertaste, making it easy to incorporate into daily routines.

Cons

• Not specifically designed for individuals with more advanced digestive issues.

• Some users may prefer higher CFU counts for more potent effects.

5. Toniiq Ultra High Strength Akkermansia Muciniphila Probiotic 10 billion n-AFU

Review

Toniqq Ultra High Strength Akkermansia Muciniphila Probiotic offers a potent formula designed to support gut health with an impressive 10 billion n-AFU per serving. Known for its role in gut microbiome support, Akkermansia Muciniphila is a probiotic that helps maintain a balanced digestive system. This supplement is designed for both men and women and focuses on promoting overall gut wellness, digestion, and immunity.

The formula features delayed-release capsules to ensure the probiotics reach the gut intact, maximizing their benefits. Each batch undergoes rigorous third-party testing for purity and potency, ensuring users get a product free from contaminants. Despite some mixed customer feedback, with reviews mentioning packaging issues, like LJ, other users, report noticeable improvements in gut health. She shared that her gut feels better since starting the supplement, showing promising results for digestive support.*

Pros

• Contains 10 billion n-AFU per serving for powerful probiotic support.

• Designed with delayed-release capsules to enhance absorption.

• Third-party tested for purity, potency, and product effectiveness.

• Supports digestive health for both men and women.

• Manufactured under strict quality control standards.

Cons

• Some customers have reported packaging issues, including unsealed lids, which may affect initial impressions.

• A few customers have expressed concerns about the effectiveness based on personal experience.

6. The Akkermansia Company™ Healthy Weight Supplement 30 Billion TFU - 30 Servings | $62.95

Review

Akkermansia Company Healthy Weight Probiotic offers an advanced formula that combines the benefits of 30 billion cells of pasteurized Akkermansia muciniphila with additional nutrients like Vitamin D, Vitamin B2, and chromium. This potent blend supports gut health and weight maintenance, making it an excellent choice for individuals seeking holistic wellness. The inclusion of GLP-1 probiotic technology provides up to 100x more Akkermansia muciniphila than other products, further enhancing its gut health benefits.

The supplement is also enriched with EGCG from green tea extract, known for its role in weight management and healthy metabolism. Free from artificial colors, flavors, and preservatives, it’s designed to cater to diverse dietary needs, being lactose-free, gluten-free, GMO-free, and vegetarian. Customers like Jessica have praised its effectiveness, stating, "Works great. Was on the pricier side, but I am very satisfied with the results." Additionally, its no-refrigeration-required feature ensures convenience for daily use.

Pros

• Contains 30 billion cells of pasteurized Akkermansia muciniphila for superior gut health support.

• Enriched with Vitamin D, Vitamin B2, and chromium for added nutritional benefits.

• GLP-1 probiotic delivers up to 100x more Akkermansia muciniphila than similar products.

• Features EGCG from green tea extract for weight management support.

• Free from gluten, lactose, GMOs, and artificial additives; suitable for vegetarians.

• No refrigeration required; maintains CFU count until expiration.

Cons

• Higher price point compared to similar probiotics.

• Contains additional ingredients like maltodextrin and croscarmellose sodium, which some users may prefer to avoid.

7. Codeage Advanced Symbiotic 100 million AFU - 90 Servings | $29.99

Review

The Codeage Akkermansia Muciniphila Probiotic Supplement offers a scientifically formulated blend that combines 100 million AFUs of Akkermansia muciniphila with chicory inulin, a fiber derived from chicory root, to promote gut health. Designed to provide a balanced approach to daily supplementation, this product includes a 3-month supply in each bottle, catering to users seeking long-term gut support.

Manufactured in the USA with globally sourced ingredients, the supplement is created in a cGMP-certified facility, ensuring both quality and safety. Customers appreciate its vegan, non-GMO, and allergen-free formulation, as it is free from dairy, soy, and gluten, accommodating a range of dietary preferences.

Reviews are generally positive, with users reporting effective results and affordability. Kelly C noted, "They can be taken with or without food, and the price is pretty good." However, feedback like Maria O’s highlights individual variations, stating, "My bowel movement has been very normal prior to taking this product. But since I started using this, it's no longer normal and not smooth. I hope it will improve as I use it longer." Despite mixed experiences, the product ranks as Amazon’s Choice and #94 in the Prebiotic Nutritional Supplements category.*

Pros

• Contains 100 million AFUs of Akkermansia muciniphila per serving for gut health support.

• Enhanced with chicory inulin fiber for additional prebiotic benefits.

• Vegan, non-GMO, and free from dairy, soy, and gluten.

• Manufactured in a cGMP-certified facility in the USA.

• Comes in a 3-month supply for convenience.

• Affordable price point with positive reviews about its effectiveness.

Cons

• Some users report changes in bowel movements that may require adjustment over time.

• Lower AFU count compared to certain higher-strength probiotic supplements.

8. Vitamatic Akkermansia Muciniphila Gut Health 1 Billion AFU - 60 Servings | $22.49

Review

The Vitamatic Akkermansia Muciniphila Gut Health supplement is a prebiotic and probiotic formula designed to support digestive health. Each serving delivers 1 billion AFUs of Akkermansia muciniphila combined with Prebiotic Inulin Powder, which enhances its effectiveness by promoting beneficial gut bacteria growth. The product uses DRcaps capsules, which are specially designed to protect the active ingredients from stomach acid, ensuring they reach the gut intact for optimal results.

Manufactured in the USA under strict GMP standards, this supplement is free from common allergens, including soy, dairy, and gluten. It is also non-GMO and contains no artificial colors, flavors, or preservatives. Customers generally find it effective and easy to incorporate into their daily routine, with some praising its reasonable price point. Denise noted, “Very few things online turn out to do much of anything, but this already seems to be helping with digestion. Good stuff, reasonably priced.”*

However, experiences vary, as some users reported adverse effects. Deb.L shared, “My parathyroid became enlarged, and I experienced daily nausea after starting this supplement. I wouldn’t recommend it to anyone. I’m undergoing tests to address the discomfort and health concerns caused by this product.”* While it is ranked #37 in Prebiotic Nutritional Supplements on Amazon, the mixed reviews highlight the need for cautious use and consultation with a healthcare provider.

Pros

• Contains 1 billion AFUs of Akkermansia muciniphila for gut health.

• Enhanced with Prebiotic Inulin Powder for improved effectiveness.

• DRcaps capsules protect ingredients from stomach acid.

• Non-GMO, gluten-free, soy-free, and dairy-free formulation.

• Free from artificial colors, flavors, and preservatives.

• Manufactured in the USA under strict GMP standards.

• Affordable price with 60 servings per bottle.

Cons

• Reports of side effects, including nausea and throat discomfort.

• May not be suitable for individuals with specific health concerns like parathyroid issues.

• Mixed customer feedback on its effectiveness for appetite suppression.

FAQs

What does Akkermansia muciniphila do?

Akkermansia muciniphila is a Gram-negative, anaerobic bacterium that resides in the mucosal layer of the human intestine. It plays a vital role in gut health by enhancing mucus thickness, strengthening gut barrier function, and regulating immunity. This helps support a healthy gut lining. Additionally, A. muciniphila has been associated with improving digestive health, and maintaining a healthy weight. By promoting a robust intestinal barrier, it contributes to overall gut integrity and metabolic balance, making it an important microorganism for maintaining a healthy digestive system [1] [2].

What Are The Best Sources Of Akkermansia?

Prebiotic-rich foods like onions, garlic, leeks, and artichokes, along with polyphenol-rich options such as berries, nuts, green tea, and olive oil, help increase its levels. Fasting also boosts its growth, as Akkermansia feeds on intestinal mucus rather than food. Supplements, including live A. muciniphila strains or prebiotics like fructo-oligosaccharides, can further support its presence. Research shows consistent benefits from berberine, metformin, and certain antibiotics, while high-fat diets and alcohol may reduce its levels. These strategies help maintain a healthy balance of Akkermansia in the gut [3].

What Are The Negative Effects Of Akkermansia?

Akkermansia muciniphila may have negative effects, including damaging the gut barrier, increasing inflammation, and disrupting the recovery of gut microbes after antibiotic use. Differences in the method of administration and bacterial viability also may affect its impact. While early research suggests it is likely safe, more clinical trials are needed to confirm its safety and potential side effects [4] [5] [6] [7].

Can You Have Too Much Akkermansia?

While Akkermansia muciniphila can offer health benefits, excessive colonization may lead to negative effects. Over-colonization can disrupt the balance between mucin secretion and degradation, weakening the intestinal mucus layer and damaging the gut barrier. This could potentially worsen conditions like colitis and colorectal cancer (CRC). Although A. muciniphila is generally considered safe, especially at doses of up to 10 billion CFUs daily for three months, more clinical research is needed to determine its long-term safety and optimal dosage [4] [10].

Who Should Not Take Akkermansia?

People with conditions like inflammatory bowel disease (IBD), Salmonella infection, or those recovering from antibiotic treatments may not benefit from Akkermansia supplementation. Caution is also advised for individuals with Endocrine or Gynecological Disorders, such as Polycystic Ovary Syndrome (PCOS) or endometriosis, which may increase the risk of developing IBD. Additionally, those with neurological conditions like Parkinson's disease or multiple sclerosis should approach Akkermansia with care, as its abundance in their gut microbiota may pose risks. Always consult a healthcare provider before starting supplements, especially for individuals with weakened immune systems or severe diseases [11].

How Long Should You Take Akkermansia For?

Akkermansia can be taken daily, and its duration largely depends on the benefits you experience. Clinical studies have typically administered it for up to 3 months (e.g., 90 days) with dosages of 10 billion bacteria per day. After this period, whether to continue or adjust the dosage should be based on individual results and guidance from a healthcare provider. It is essential to monitor its effects and consult a professional if you plan to take it for an extended period [12] 

Does Akkermansia Cause Weight Loss?

Emerging research suggests that supplementing with this microorganism may support healthy cholesterol levels and promote metabolic health in overweight or obese individuals when compared to a placebo group. These benefits may be linked to Akkermansia's role in maintaining energy balance and supporting overall metabolic function. Additional studies are needed to further explore its potential effects. [13] [14].

Conclusion

With a plethora of Akkermansia supplements available on the market, choosing the right one can be overwhelming. Some best brands of Akkermansia like Toniiq, Pendulum, Double Wood, Codeage, and SuperSmart offer a variety of options to suit individual needs. It's essential to consider factors such as dosage, quality of ingredients, and overall reputation when making a decision. Always consult with a healthcare professional before starting any new supplement regimen.