l-theanine and-5-htp

L-Theanine and 5-HTP: Which One Is Better?

In the midst of a fast-paced life, maintaining mental well-being has become a top priority. Prolonged stress can lead to burnout, leaving everything in disarray and your mind exhausted.

Among countless relaxation-supporting compounds, L-Theanine and 5-HTP stand out for their ability to reduce stress and enhance mood. But which one is the right choice for you?

Should you take them individually or combine both for optimal results? Dive into the article below to find the answer and regain your balance!

Before exploring further, please read the disclaimer located at the end of this webpage.

Key Takeaways

  • L-Theanine: Promotes relaxation and focus; best for daytime use.
  • 5-HTP: Boosts serotonin and sleep quality; best for nighttime use.
  • Work differently: L-Theanine calms, 5-HTP increases serotonin.
  • Can be combined (morning–evening), but long-term safety is unclear

Understanding L-Theanine: The Zen Amino Acid

L-Theanine is found in tea leaves

L-Theanine is an amino acid commonly found in various types of tea, such as green tea, black tea, and certain mushrooms. Its effects include supporting the transmission of "signals" from the brain to different organs in the body and vice versa.

As a result, users who supplement with an appropriate amount can significantly enhance their concentration and respond quickly to environmental stimuli. But does L-Theanine make you sleepy?

Moreover, L-Theanine has a strong connection with GABA, dopamine, and serotonin in the brain, forming a synergistic relationship that boosts mood, enhances alertness, and alleviates stress effectively [3].

A unique aspect of L-Theanine is its ability to relax the nervous system without inducing drowsiness. Imagine waking up in the morning, taking a sip of hot tea, and feeling your mind instantly refreshed, ready to embrace a new day full of energy. That’s the experience L-Theanine provides [4].

Recognizing the remarkable benefits of L-Theanine, many manufacturers have utilized this nutrient to create dietary supplements in capsule or tablet form, allowing users to conveniently enjoy the product according to their needs and purposes.

Based on a survey of user comments on an L-Theanine-containing supplement on Amazon, most users reported that it helped improve their sleep quality, wake up feeling refreshed, and feel more relaxed and calm.*

Exploring 5-HTP: The Serotonin Booster

5-HTP (short for 5-hydroxytryptophan) is a compound naturally produced by the body after converting tryptophan [5]. Tryptophan is found in various foods, including eggs, brown rice, bananas, and beans.

Once the body absorbs 5-HTP, it is further converted into serotonin—a precursor to melatonin, which plays a crucial role in sleep quality and brain alertness.

This means 5-HTP supports neurotransmission similarly to L-Theanine. Additionally, it aids in stimulating smooth muscle contractions, promoting a sense of relaxation and happiness, while also enhancing cell production and division [6].

The process of 5-HTP conversion

It is important to note that 5-HTP does not exist in any food, but is only obtained when tryptophan is metabolized in food. Therefore, if you want to get enough 5-HTP for your body every day, of course you have to supplement tryptophan.

However, many units have found 5-HTP as a chemical by-product in the process of harvesting and processing the seeds of an African tree called Griffonia simplicifolia. Therefore, the idea of supplementing 5-HTP through this tree is indeed a worthy idea [7].

L-Theanine benefits are noted by Amazon users.

Through the analysis of 5-HTP and L-Theanine above, you must have realized that both of these substances have a positive effect on your frequent poor concentration, stress, etc, right?

But is your body suitable for using both? Or just a certain type? If you want to significantly improve your stress, can you use both active ingredients together? Please continue reading below for the answer.

L-Theanine vs. 5-HTP: A Head-to-Head Comparison

Although L-theanine and 5-HTP both aim to improve concentration and reduce stress, the way each substance works is different.

In particular, L-theanine has the ability to cross the blood-brain barrier, directly affecting the brain. Thanks to that, it soothes the tension in the brain's nervous system, so the serotonin and dopamine active substances increase.

In addition, L-theanine also acts as a powerful antioxidant to limit any attacks from harmful substances (often occurring when stress is excessive, cortisol increases).

In addition to drinking tea to supplement L-Theanine, using supplements containing L-Theanine also brought many positive effects. Up to 89.8% of users gave positive reviews (4 stars or more) about a supplement on Amazon. Among them, a user named Edgar expressed that he slept well, fell asleep faster than usual.*

In contrast, the way 5-HTP works is to improve serotonin production from the beginning. At a necessary level, the body no longer has excess cortisol levels, so the body gradually stabilizes, is not too stressed and becomes more alert.

Similarly, many users have also tried 5-HTP and felt many positive effects. For example:

  • Hanna Perriello spent a long time struggling with depression. When using 5-HTP, she feels her body is lighter and more focused.*
  • Jered always lives in a state of anxiety even though life has no problems. After using 5-HTP, Jered feels much more comfortable and relaxed. Dosage: 1 capsule/day.*
  • Kai Smith found that 5-HTP brings emotional balance.*

In addition, L-theanine is most effective during the day, when it improves the concentration level needed by the body. But 5-HTP mainly focuses on the quality of sleep at night, after stabilizing the substances in the body, the body can sleep better, deeper, so it will be better focused during the day.

To help readers visualize these two active ingredients more easily, below is a summary table of information and detailed comparison:

Criteria

L-theanine

5-HTP

Origin

In green tea, black tea, mushrooms, ...

Converted from foods containing tryptophan or seeds of the Griffonia simplicifolia plant

Taste

Can create a salty (umami) taste in tea

Light citrus flavor

Purposes

Used as a dietary supplement to help relax the mind, reduce stress, increase concentration, ...

Indicated to support the reduction of stress, attention deficit hyperactivity disorder,...

Potential benefits

Support cancer treatment, anti-oxidant, regulate the immune system, ...

Reduce symptoms of depression, control appetite, ...

Satisfaction rate

Nearly 55% of users confirm that the nutrient brings clear effects to them

More than 50% of users on the WebMD platform positively evaluate the benefits of 5-HTP

Only doctor's prescription

Yes

Yes

Recommended dosage

200 - 400 mg/day, continuously for 4 - 8 weeks

150 - 800 mg/day

Recommended for you:

L-Theanine Vs GABA: Is GABA Better Than L-Theanine?

Theanine Vs. L-Theanine: Are They The Same Or Different?

Potential Risks and Side Effects: Safety First

Dr. LeGrand on L-Theanine for Mood Stability

Dr. LeGrand said that when using 200 mg of L-Theanine/day, continuously for 30 days, his mood gradually stabilized after 2 weeks [1].

In addition, Dr. Jessica Norton shared in her video that the research content on the benefits of L-Theanine is real, especially the impact on GABA waves to help the body concentrate well without stress and drowsiness. With the dosage used, 200 - 800 mg/day is considered safe, but you should consult your doctor carefully because each person's tolerance is different [2].

Although it has been presented as effective by doctors, some users have encountered unwanted side effects. Typically, AF customers have problems with diarrhea, vomiting, and headaches in the first 3 days of use.*

Or Captain Danger feels like he often has bad dreams, and feels scared after using them. Moreover, some other consumers also feel their heart beats much faster, feeling similar to drinking high doses of caffeine.*

5-HTP is also shown to be effective by many people. Youtube Your Inception actively used 2 capsules containing 5-HTP (equivalent to 200 mg/day) and noticed his body changed completely after only 1 week - comfortable mood, very good concentration.


However, a user on WebMD shared that the body's demand for 5-HTP is increasing, but the effectiveness has not changed much. Initially, the user only used 50 mg but now after 8 months has reached 400 mg and the condition of rapid heartbeat, slow breathing occurs frequently. Furthermore, Ali also experienced similar symptoms such as body shaking, restlessness, and difficulty sleeping after using 5-HTP for 2 days.*

With the above problems, we can judge that their bodies are not suitable for using both active ingredients. Or maybe they have abused those active ingredients and become dependent, making the body unable to concentrate or sleep well without them. In addition, before using any functional food, you should have a thorough health check-up and consult your doctor about dosage and detailed usage to ensure safety.

L-Theanine and 5-HTP: Can They Be Used Together?

There is no exact answer to whether L-Theanine and 5-HTP can be used together, although both bring undeniable health benefits.

Such a combination can theoretically reduce side effects, specifically L-Theanine helps balance cortisol levels and supports the formation of alpha brain waves while 5-HTP contributes to faster serotonin production. From there, users feel healthy and alert quickly.

This has been tested by some users on Reddit, in which they often drink green tea (with L-Theanine in the morning) and use functional foods with 5-HTP in the evening. They find that they are always alert and sleep well. However, there is no experience of long-term use with any side effects.*

This raises a concern: Could 5-HTP’s potential to rapidly influence cortisol affect health? There is absolutely no answer for this case because the response ability of each person is different. Moreover, the dosage of each substance is different, so in general, if you want to use them together, please consult your doctor.

Conclusion

The above is an analysis of the benefits and side effects (if any) of L-theanine vs 5-htp. It can be seen that each substance has a separate way of affecting the body, but in general, they all bring benefits to the body in relieving stress, improving concentration and sleep quality.

However, not everyone can respond to this active ingredient, so before using it, you should consult your doctor. At the same time, using l-theanine vs 5-htp is only a support method, you should not completely depend on it but build a scientific and healthy diet and lifestyle to effectively nourish a clear mind, comprehensive health, and safety.

References

  • [1] (2025). Retrieved March 9, 2025, from Youtube.com website: https://www.youtube.com/watch?v=EfrmG7YsFMM&list=TLGGwbavnfDyeHAwOTAzMjAyNQ.
  • [2] (2025). Retrieved March 9, 2025, from Youtube.com website: https://www.youtube.com/watch?v=o5OYC4daQ-c&list=TLGGvbaLPgzPJJIwOTAzMjAyNQ.
  • [3] PJ;Lu, N. (2019). The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. Journal of Herbal Pharmacotherapy, 6(2). https://pubmed.ncbi.nlm.nih.gov/17182482/
  • [4] Sissons, C. (2019, January 8). Does L-theanine have health benefits? Medicalnewstoday.com; Medical News Today. https://www.medicalnewstoday.com/articles/324120
  • [5] Liu, X.-X., Zhang, B., & Ai, L.-Z. (2021). Advances in the Microbial Synthesis of 5-Hydroxytryptophan. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.624503
  • [6] Maffei, M. E. (2020). 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. International Journal of Molecular Sciences, 22(1), 181–181. https://doi.org/10.3390/ijms22010181
  • [7] 5-Hydroxytryptophan (5-HTP) Information | Mount Sinai - New York. (2015). Mount Sinai Health System. https://www.mountsinai.org/health-library/supplement/5-hydroxytryptophan-5-htp

Testimonial Disclaimer

*The testimonials presented on this website are provided by individuals based on their personal experiences with our products. These testimonials represent individual opinions and experiences, which may not be typical or applicable to all users of our products. Results may vary depending on a variety of factors, including individual health, lifestyle, and adherence to product usage instructions.

Author

Ralph S Albert
Ralph S Albert
Ralph S. Albert is an esteemed professional with a remarkable career spanning over 15 years in the dynamic and ever-evolving realm of the food and nutrition industry. Currently, Ralph proudly serves as the Head of Research at Vinatura Supplements, a leading company in the dietary supplement industry. His work is characterized by a dedication to innovation, compliance, and the application of scientific research to create natural, yet practical solutions for consumers.
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