12 Best Phosphatidylserine Supplements For Brain Health

Our brains, much like well-oiled machines, require specific nutrients to function optimally. Among these, Phosphatidylserine (PS) stands out as a phospholipid, a type of fat that's a key building block of brain cell membranes.

A recent 2024 study published in PubMed highlights the potential of PS, particularly when combined with ALA, to improve cognitive functions (Duan et al., 2024) [1].

But here's the catch: While PS shows promise, the market is flooded with supplements, each claiming superior benefits4. So, how do you navigate this complex landscape to choose the best Phosphatidylserine supplement for your brain health?

This article will cut through the noise, examining the top contenders and providing evidence-based recommendations to help you make an informed decision.

Here is the short list of the best Phosphatidylserine Supplements for brain health that we will introduce to you:

Vinatura Phosphatidylserine Rhodiola Rosea | $27.89

THORNE Phosphatidylserine (Formerly Iso-Phos)| $63

Double Wood Phosphatidylserine Supplement | $19.53

Nutricost Phosphatidylserine 400mg, 120 Capsules | $26.97

DEAL SUPPLEMENT Phosphatidylserine Supplement, 400mg Serving | $28.95

Solgar Phosphatidyl-Serine 200 mg, 60 Softgels | $45.59

Comparison Table of the Best Phosphatidylserine Supplements

How Do We Choose The Best Phosphatidylserine Supplements?

Safety

We prioritize products that carry certifications from well-known independent testing organizations such as NSF International or USP (United States Pharmacopeia) or other famous independent organizations such as ARL Bio Pharma, CDC, SGS...These certifications aim to verify product purity and transparency of ingredients.

Efficacy

The effectiveness of Phosphatidylserine in supporting brain function has been documented through multiple studies. Based on these findings, we prioritize products with scientifically supported formulations containing ingredients tested and verified by reputable research bodies. These products have also undergone independent third-party testing to ensure real health benefits and measurable wellness impacts.

Dosage

Appropriate dosing is a critical factor for the effectiveness of each product. Each product on our list provides a Phosphatidylserine dosage per serving ranging from 100-300 mg per use, aligning with expert recommendations. At the same time, products with dosages outside this range are excluded to ensure safety and deliver efficient results.

Price

Price transparency is also an important consideration. We provide various products across various price points to accommodate diverse financial needs. Phosphatidylserine supplements range from $20 to $80.

This wide price range reflects the value of each product, which largely depends on advanced formulations, ingredients, and certifications from laboratories. Products priced between $60 and $80 are geared toward high-purity options with enhanced bioavailability features, while more standard options may be available from $20.

Convenience

Finally, convenience is essential in today’s busy lifestyles. We prioritize products that are easy to use daily, including convenient formats like capsules, chewables, or powders that can be taken quickly and easily carried. The following convenient and portable options are ideal for individuals with busy schedules.

13 Best Phosphatidylserine Supplements For Brain Health:

Vinatura Phosphatidylserine Rhodiola Rosea | $27.89 | Best for Focus, Memory, Relax Support

Why Do We Choose It?

Vinatura Phosphatidylserine Rhodiola Rosea offers a targeted blend designed to support cognitive function and promote relaxation. Each serving delivers 300mg of Phosphatidylserine and 900mg of Rhodiola Rosea, with the formula standardized to 3% Rosavins and 1% Salidrosides.

This carefully engineered combination is intended to support focus, memory, and processing speed while supporting healthy stress levels and overall brain performance.

Manufactured in the USA in a cGMP-certified facility and third-party tested, this supplement is crafted with a commitment to quality and transparency. Sourced from white kidney beans, the Phosphatidylserine is completely soy-free, and the product is vegan as well as free of gluten, soy, tree nuts, and dairy.

Customers have appreciated the clean formulation and the straightforward approach that avoids unnecessary fillers or artificial ingredients.

One thing that impressed me about this product is the brand’s steadfast commitment to transparency and quality. This isn’t just marketing hype – you can easily verify its credibility through readily available certifications and testing results on the product page. Moreover, real user reviews underscore that many have found it to be a product worth trying and effective.

You can see this in more detail through the reviews of customers who have used this supplement. For example, Vicki said, “Good quality. I really like how I’ve been able to keep more focused at work and home.”*

Or Mrs. Suzy Lazaro said: “I’ve taken Phosphatidylserine alone for years, but this combo with Rhodiola makes me feel good and sharpens my memory!”*

Pros

• Supports focus, memory, cognitive performance, and endurance
• Vegan and free from common allergens
• Manufactured in the USA with third-party testing and cGMP certification
• Reasonably priced
• Unique formula combining Phosphatidylserine and Rhodiola Rosea to enhance brain health and promote comfortable relaxation

Cons

• Not suitable for those allergic to Rhodiola

Double Wood Phosphatidylserine Supplement | $19.53 | Best for Brain Health Support

Why Do We Choose It?

Double Wood’s Phosphatidylserine Supplement is a high-potency brain health supplement designed to support memory and attention. Manufactured in the USA from globally sourced ingredients, this supplement is Non-GMO and gluten-free, aligning with the brand’s commitment to pure, potent supplements backed by third-party testing.

With over 5,500 reviews on Amazon and more than 6,000 units sold monthly, this Amazon-recommended product is one of the most popular Phosphatidylserine (PS) supplements available. Impressively, 86% of customer reviews are positive, reinforcing its strong reputation for quality and effectiveness.

Additionally, Double Wood offers bulk purchasing options such as double and triple packs, providing better value for repeat buyers. However, one important consideration is that this product contains soy, which may not be suitable for individuals with soy allergies.

Pros

• Affordable price
• Easy to use
• Supports brain health effectively
• Manufactured in the USA

Cons

• The product contains soy, so some people allergic to soybeans should take note

THORNE Phosphatidylserine (Formerly Iso-Phos)| $63 | Best for Cortisol Management Support

Why Do We Choose It?

THORNE Phosphatidylserine is an Amazon’s Choice supplement designed for cortisol management and overall wellness.

Each capsule delivers 100mg of Phosphatidylserine Isolate, combined with naturally derived flavors and colors, making it gluten and dairy free. Packaged as 60 capsules per bottle, this product is tailored to support cognitive function, focus, and improved sleep quality, all while assisting in stress management.

Manufactured by Thorne—a brand trusted by professional athletes and partnered with esteemed organizations such as the Mayo Clinic and multiple U.S. Olympic Teams—this supplement undergoes rigorous quality assurance.

It has been subjected to four rounds of third-party testing to ensure that the label accurately reflects its contents and that it is free from contaminants like heavy metals, pesticides, and microorganisms.

While many users have noted significant improvements in sleep quality and overall performance, the product’s higher price point is often mentioned as a consideration. Additionally, although the majority of feedback is positive, there have been isolated reports of adverse experiences.

For example, one user Ra$TeR who used Phosphatidylserine for over a decade initially observed beneficial effects on sleep; however, following a head injury, they experienced severe insomnia and symptoms of hyperthyroidism, which resolved after discontinuing the supplement. Such mixed experiences highlight that individual responses to the product may vary.

Pros

• Amazon’s Choice for Cortisol Management Support
• Contains 100 mg of Phosphatidylserine Isolate per capsule
• Derived from natural ingredients; gluten and dairy free
• Undergoes four rounds of rigorous third-party testing
• Trusted by professional athletes and partnered with renowned organizations
• Reported to enhance sleep quality, cognition, and stress management

Cons

• Premium pricing at approximately $1.05 per capsule
• Some users have reported adverse effects over long-term use
• Not all customers experience the desired benefits consistently

Nutricost Phosphatidylserine 400mg, 120 Capsules | $26.97 | Best for Brain Health Support

Why Do We Choose It?

This product provides 400mg of Phosphatidylserine at a reasonable price and provides a cost-effective option for those interested in maintaining their cognitive wellness.

With this product, typical feedback and countless approvals from Heather say: “Wasn’t sure what to expect at such a great price, as you tend to get what you paid for. This works as well or better than any Phosphatidylserine I have ever tried. I found that 2 capsules worked well for me. I wake up with some hypervigilance sometimes. Definitely my new go-to for PS.”*

Pros

• Reasonable price
• Large, economical packaging
• No other additional ingredients

Cons

• Slightly large capsules
• Not always available

LongLifeNutri Phosphatidylserine Pure 500mg | $23.90 | Best for Strengthening Memory

Why Do We Choose It?

LongLifeNutri Phosphatidylserine Pure 500mg is a high-quality dietary supplement focused on enhancing memory and cognitive function. Packaged as 180 vegetarian pills for a three‐month supply, this product is proudly made in the USA, lab tested, soy free, and non-GMO. It also comes with a one-year satisfaction guarantee.

The formula is meticulously crafted using Phosphatidylserine derived from non-GMO sunflower lecithin, along with vegetable cellulose for the capsules and magnesium stearate from a vegetable source. This high-concentrated dosage per serving is designed to support mental clarity, and improve sleep quality.

Customers have found the product effective and reasonably priced, noting its role in bolstering overall cognitive performance.

Greg, a single father with a busy work schedule, rated the product five stars and praised its attractive packaging and timely delivery, though he did caution that the supplement may require at least one month to show noticeable effects.

While many users appreciate its benefits, there have been some mixed reviews. Several customers mentioned an unpleasant smell and difficulty reading the label, which may affect the overall experience.

Pros

• 180 vegetarian pills providing a three-month supply
• Focused on memory enhancement and cognitive support
• Made in the USA, lab tested, soy free, and non-GMO
• Comes with a one-year satisfaction guarantee and a free premium pill organizer
• High-concentrated dosage per serving for optimal effectiveness

Cons

• Some users report an unpleasant smell
• Label design may be difficult to read for certain customers
• Effects may take at least one month to become evident

X Gold Health Phosphatidylserine & Bacopa Monnieri 400 mg 2 in 1 Supplement | $29.98 | Best for Enhanced Focus

Why Do We Choose It?

X Gold Health Phosphatidylserine & Bacopa Monnieri 400 mg 2 in 1 Supplement offers a powerful dual-action formula designed to boost cognitive performance and enhance memory. Combining 400mg of Phosphatidylserine from non-GMO sunflower lecithin with 400mg of Bacopa Monnieri, this supplement helps your brain work at full throttle.

Bacopa Monnieri is an ancient Ayurvedic herb celebrated for its antioxidant properties and ability to support brain function, making the synergy between these two ingredients more potent than either one alone. With over 500 purchases each month, its growing popularity speaks to its effectiveness and value.

The unique 2 in 1 formulation not only supports cognitive function and memory but also aids in overall mental clarity and stress management. Applied for nootropic and adaptogenic purposes, the blend offers excellent value compared to purchasing the ingredients separately, while being suitable for people of all ages.

Made in the USA, NON-GMO, and gluten free, this supplement caters to health-conscious consumers seeking a reliable and clean product. Customer feedback underscores its benefits. One Amazon reviewer, Mr. Alfredo O., shared:

“I felt that my ability to retain information improved during my study period within 3 weeks of study. I crammed a lot of information in a very short period, yet I was able to retain information better than normal and pass an exam that most people don't pass on their first attempt. I also had much stress from work, and I would combine it with L-Theanine.”

Such testimonials highlight the product’s capacity to enhance focus and support cognitive resilience.

Pros

• 2 in 1 formula combining 400mg Phosphatidylserine and 400mg Bacopa Monnieri for enhanced brain performance
• Supports cognitive function, memory, and focus across all age groups
• Applied for nootropic and adaptogenic purposes
• Excellent value compared to purchasing ingredients separately
• Made in the USA, NON-GMO, and gluten free
• Popular with over 500 purchases per month

Cons

• The price is a bit high compared to other products of the same type

NusaPure Phosphatidylserine Memory Ultimate Complex 1000mg 200 Vegetarian Caps | $26.78 | Best for Memory

Why Do We Choose It?

NusaPure Phosphatidylserine Memory Ultimate Complex 1000mg is a premium cognitive support supplement formulated to enhance mental clarity, memory, and concentration.

This advanced complex features a potent blend of Phosphatidylserine, L-Serine, Gingko Biloba, Gotu Kola, Rosemary Leaf, and DMAE, offering a comprehensive approach to cognitive function. Assembled in the USA under cGMP standards with third-party testing, and certified vegan and non-GMO, this supplement is designed to meet rigorous quality benchmarks.

With over 900 purchases each month and an impressive 4.5-star rating from 998 reviews, customers have praised its effectiveness in improving focus, recall, and even sleep quality.

Packaged as a 200-count bottle, NusaPure is ideal for long-term use, although newcomers might need to consider the larger supply before fully committing to the regimen. Overall, users have found this nutritional supplement to be not only effective but also excellent value for those seeking enhanced cognitive performance.

Pros

• Potent blend of Phosphatidylserine, L-Serine, Gingko Biloba, Gotu Kola, Rosemary Leaf, and DMAE for comprehensive cognitive support
  
• Manufactured in the USA under cGMP standards, third-party tested, vegan, and non-GMO
• Over 900 monthly purchases with a 4.5-star rating from 998 reviews
• 200-count bottle ideal for long-term use
• Reported improvements in memory, concentration, focus, recall, and sleep quality
• Easy-to-swallow capsules offering excellent overall value

Cons

• Contains soy, which may be unsuitable for individuals with soy allergies
• The large 200-capsule count might be overwhelming for beginners or those looking to try a smaller supply

Natural BioScience Soy Free Phosphatidylserine 100mg | $39.95 | Best for Brain Health, Memory Aid

Why Do We Choose It?

Natural BioScience Soy Free Phosphatidylserine 100mg is an Amazon’s Choice product and ranks #29 in Lecithin Nutritional Supplements. It comes in two options—90-count and 60-count—giving users flexibility in their purchase.

This supplement is in softgel form, which is often preferred for better absorption and ease of swallowing compared to capsules or tablets. Additionally, it is Soy-Free & Non-GMO and features Sharp PS100, a patented form of Phosphatidylserine designed for maximum potency, absorption, and bioavailability.

According to the manufacturer, this supplement offers multiple cognitive and brain health benefits, including memory and learning support, enhanced mental sharpness, cortisol regulation, and improved focus and clarity.

But is this a perfect, all-in-one solution? Based on reviews from various sources, it appears effective but not exceptional. On Amazon, 67% of users gave it a 5-star rating, while 23% rated it 4 stars, and less than 5% rated it 1, 2, or 3 stars.

This suggests that while most users are satisfied, a noticeable percentage feel the product does not fully meet expectations.

Pros

• Soy-free, safe for those with allergies
• Supports memory and enhances cortisol management
• Certified Non-GMO

Cons

• The 100mg dosage of Phosphatidylserine is considered lower compared to other products.

Solgar Phosphatidyl-Serine 200 mg, 60 Softgels | $45.59 | Best for Supporting Cognitive Function

Why Do We Choose It?

Solgar is a well-established supplement brand, founded in 1947, with a strong reputation in the nutrition industry. Its products are widely distributed worldwide, from Europe to Asia, proving their quality and reliability.

Solgar Phosphatidyl-Serine 200 mg, 60 Softgels is a premium brain health supplement derived from natural sources. The formula includes Gelatin, Medium Chain Triglycerides, Vegetable Glycerin, and Natural Caramel Color, ensuring optimal absorption.

Notably, it is free from gluten, wheat, yeast, sugar, salt, artificial flavors, artificial sweeteners, and artificial preservatives, making it suitable for individuals with strict dietary needs.

A major advantage of this product is its heat-resistant glass bottle, which helps protect the softgels from light, moisture, and mold. Additionally, Solgar emphasizes recyclability, reflecting its commitment to sustainability and community responsibility.

However, not all customers have had a perfect experience. Some users have reported issues with the softgel quality, particularly leakage. One Amazon customer received a leaking bottle in December and struggled to get a refund, even after contacting Amazon twice. Given the high price point, this was a disappointing experience, although such issues are not typical for Solgar.

Pros

• High potency
• Quality product from a trusted brand
• Supports memory and cognitive function

Cons

• High price
• Sometimes, it is difficult to order and has issues with the softgel quality

DEAL SUPPLEMENT Phosphatidylserine Supplement, 400mg Serving | $28.95 | Best for Brain Health Support

Why Do We Choose It?

This product is an Amazon Choice item, ranking #8 in Lecithin Nutritional Supplements with over 1,000 purchases per month. It holds an impressive 4.5-star rating from more than 1,000 reviews, indicating strong customer satisfaction.

However, based on experience, the number of reviews is often much lower than actual purchases, as not everyone takes the time to leave feedback. Therefore, the review count may not fully reflect real user experiences.

A deeper analysis of the ratings shows that 72% of users gave it 5 stars, and 16% gave it 4 stars, making a total of 82% positive feedback—a generally solid score. However, 4% of users rated it 1 star, which is worth considering.

Many of these negative reviews mention side effects, such as "Gave me a weird twitch in my eye!"* and "Caused headaches."* Additionally, some customers reported that the product was non-returnable, which could be frustrating.

The supplement features Phosphatidylserine (PS) powder-filled capsules, derived from premium soy-free sunflower lecithin and encapsulated in California. It is standardized to retain 20% active PS.

The product mainly supports brain health and stress management for both men and women. Since PS is a crucial healthy brain fat that naturally depletes over time, taking 400mg daily may help restore its levels.

Additionally, the formula is made with non-GMO ingredients, 3rd party lab-tested for quality, and is free from gluten, dairy, eggs, peanuts, soy, wheat, and yeast, making it suitable for those with dietary restrictions.

Pros

• High dosage, good effect
  
• Reasonable price
• Contains no allergens
• Ranking #8 in Lecithin Nutritional Supplements
• 82% positive feedback on Amazon’s review

Cons

• No other additional ingredients
  
• It may cause side effects if used in excess
• Non-returnable

Integrative Therapeutics Phosphatidylserine | $48.25 | Best for Brain Function and Stress Support

Why Do We Choose It?

Integrative Therapeutics Phosphatidylserine is derived from sunflower oil, making it 100% soy-free. While most studies have focused on soybean-derived or bovine-sourced PS, sunflower-derived PS is chemically identical to these alternatives [2]. This makes it an excellent choice for those looking to avoid soy or animal-based sources.

The product contains 100 mg of Phosphatidylserine per softgel, utilizing the Sharp•PS® formula from Frutarom. Other ingredients include medium-chain triglycerides, gelatin, glycerin, sunflower lecithin, and preservatives to maintain freshness.

Many customers appreciate its benefits in improving sleep quality, enhancing memory retention, and promoting a calming effect. Additionally, its soy-free composition makes it a great option for those with soy allergies.

However, there are some drawbacks. While 80% of users leave positive reviews, 13% have rated it 1 star on Amazon. A common issue mentioned in negative reviews is that the softgel capsules tend to stick together.

This could be due to storage conditions, packaging quality, or the softgel formulation itself. Additionally, some customers feel that the price is on the higher side compared to other PS supplements.

Pros

• Formula to support stress reduction
• GMP certification ensures quality
• Free of gluten and harmful additives
• 80% customers give the positive feedbacks
• Utilizing the Sharp•PS® formula from Frutarom

Cons

• Price is higher than similar products
• Softgel capsules tend to stick together

We Like Vitamins Phosphatidylserine Supplement with Ginkgo Biloba, Gotu Kola, DMAE | $24.99

Why Do We Choose It?

The product combines Phosphatidylserine with herbal ingredients such as Ginkgo Biloba and Gotu Kola, which help enhance memory and concentration and are ideal for those looking to support their overall cognitive health.

LJSC's sharing will undoubtedly be very meaningful for those who need help with sleep:

“The brain fog, memory lapses, and word searching were daily issues that seemed to only increase. I've never been a good sleeper, but my lack of sleep was becoming almost debilitating…I am happy to say that I feel some positive changes in my mental clarity and focus. I seem to be searching for words less, and I am definitely sleeping better again.”*

• Pros
• Formulated with an herbal combination and Phosphatidylserine
• Helps improve memory and cognition
• High nutritional value

Cons

• The price is higher than conventional products

Conclusion

Phosphatidylserine is an excellent supplement that may contribute to overall cognitive wellness. With the products mentioned, you may improve neurological functions, achieve better memory for work and study, and maintain a cheerful and alert spirit to alleviate the pressures of a busy life.

Brands like Vinatura Supplements, THORNE, and Solgar are all excellent choices that contain Phosphatidylserine, so don't hesitate to choose the product that suits you best!