Is Fadogia Agrestis Toxic? Side Effects On Liver And Kidney

Is Fadogia Agrestis Toxic? Fadogia Agrestis may cause undesirable side effects on the liver and kidneys if used in high doses over a long period. Therefore, it's important to be aware of these potential side effects and take necessary precautions to use Fadogia Agrestis safely.

Is Fadogia Agrestis Toxic?

Fadogia Agrestis, an herb from the Rubiaceae family, is highly renowned in traditional medicine. This plant originates from Africa, and its main compounds are known for their ability to treat various ailments, particularly the benefits of Fadogia Agrestis include enhancing performance and sexual pleasure for men.

So, does Fadogia Agrestis contain toxicity? Numerous animal studies have indicated that this herb has significant toxicity and can cause serious damage to vital organs such as the liver and kidneys when used in high doses or for extended periods [1] [2] [3].

Common Side Effects And Toxicity Of Fadogia Agrestis

Using Fadogia Agrestis for extended periods at high doses without the supervision or advice of healthcare professionals can lead to side effects and symptoms of toxicity, such as:

• Side effects: Vomiting, headaches, loss of voice, skin irritation such as redness and itching, nausea, and effects on sleep quality.
• Toxicity symptoms in vital organs: In the liver, it can cause degeneration and tissue death (also known as necrosis), and in the kidneys, it may lead to chronic nephritis.

Read more: How Long Does Fadogia Agrestis Take to Work?

What Are The Side Effects And Toxicity Of Fadogia On The Liver?

A 2009 study [1] lasting 28 days on mice showed that Fadogia Agrestis can be toxic to the liver. Specifically:

Study Design: The subjects were female mice divided into 4 groups. Three of these groups were administered Fadogia Agrestis extract at 18, 50, and 100 mg/kg of body weight, respectively.

Results:

• Reduced liver enzyme activity: Serum levels of liver enzymes (ALP, GGT, LDH) increased, but their activity in the liver decreased. This indicates that after using Fadogia Agrestis, there were signs of liver damage or dysfunction.
• Increased MDA levels: MDA, a marker of oxidative stress, significantly increased in this study, suggesting that Fadogia Agrestis extract may cause damage to cell membranes.

Although clinical toxicity symptoms or death were not observed, the study demonstrated that Fadogia Agrestis can have adverse effects on the liver, particularly with long-term use or high doses, which could compromise liver structural integrity.

What Are The Side Effects And Toxicity Of Fadogia On The Kidney?

A 2008 study [2] lasting 21 days on male mice showed that Fadogia Agrestis affects kidney function with long-term use. Specifically:

Study Design: The subjects were 20 male white mice divided into 4 groups. Three of these groups were administered Fadogia Agrestis extract for 21 consecutive days at 18, 50, and 100 mg/kg doses.

Results:

• Increased uric acid and creatinine levels are key indicators of kidney filtration function, and their increase suggests that kidney dysfunction is developing. The study showed that Fadogia Agrestis causes kidney impairment, as the serum levels of these substances increased significantly.
• Increased levels of sodium, potassium, and calcium ions: These substances also significantly increased in the serum after Fadogia Agresti's use, indicating electrolyte imbalance and impaired kidney function.
• Decreased levels of urea and bicarbonate: This reflects a reduction in the kidneys' detoxification capability following Fadogia Agresti's use.

Therefore, Fadogia Agrestis can cause kidney dysfunction, decreased detoxification ability, and overall decline in kidney function.

What Are The Factors Influencing The Severity Of Fadogia Agrestis Side Effects?

The level of impact of Fadogia Agrestis may depend on the following three factors:

• Dosage: Using Fadogia Agrestis at high doses can lead to toxicity and severe side effects.
• Duration: Prolonged use without medical advice can cause serious effects on the liver and kidneys.
• Health Status: If you use Fadogia Agrestis while having pre-existing liver or kidney health issues, it may worsen the condition.

How To Prevent Fadogia Agrestis Side Effects And Toxicity

To prevent side effects and toxicity from Fadogia Agrestis, it is best to follow these three principles:

• Principle 1: Always consult a doctor, especially if you have liver or kidney conditions, and ensure you have a careful usage plan.
• Principle 2: Use according to the dosage advised by your doctor; do not increase the dosage on your own.
• Principle 3: Continuously monitor your condition and bodily reactions throughout the usage period to detect any unusual symptoms promptly. Blood tests can be performed to monitor the body's reaction to Fadogia Agrestis.

You may be interested: When to Take Fadogia Agrestis: Morning or Night?

Conclusion

Fadogia Agrestis is an herb that offers numerous health benefits, particularly in enhancing sexual function. However, this herb can also cause symptoms such as liver necrosis and chronic nephritis. Therefore, users should consult a doctor before using it to prevent health risks.