What Is NMNH Supplement? Explore 5 Benefits Of NMNH

NMNH, with its ability to increase NAD+ levels in the body more quickly and efficiently than NMN, has become a promising supplement choice for those looking to maintain health, improve energy, and slow the aging process.

But are these benefits true? And what exactly is NMNH supplementation? Let’s explore this in this article!

What Is NMNH?

NMNH (dihydronicotinamide mononucleotide) is the reduced form of nicotinamide mononucleotide (NMN) — a precursor of NAD+ (nicotinamide adenine dinucleotide).

It is a natural compound that helps enhance NAD+ levels, which are essential for the body to produce energy and support many metabolic processes. NAD+ levels decrease as we age, which is why supplementation is needed to maintain optimal levels.

NMNH is more effective than NMN at increasing NAD+ in cells, and it also has other notable effects, such as slowing the breakdown of sugars and the energy metabolism cycle (TCA), as well as preventing cells from growing too quickly [1].

What Is NMNH Supplement?

NMNH supplements are known as an effective alternative to NMN for boosting NAD+ levels in the body. As mentioned, NAD+ helps the body replenish energy and supports bodily functions.

What makes NMNH stand out is its better absorption, allowing for a faster and more effective increase in NAD+ levels. This means NMNH may be a superior choice for those looking to boost NAD+ levels to improve overall health and maintain a youthful state.

Is NMNH Safe?

According to existing research, NMNH has been safely used in mice without significant side effects [2].

Although NMNH is currently being sold on retail websites like Amazon, its safety has not been fully researched due to the lack of human safety studies. Dr. Andrew Shao noted that existing studies primarily tested NMNH through injections, so there is no specific research on the safety of oral NMNH in humans or animals [3].

However, some experts suggest that since NMNH and NMN have similar structures, NMNH may also be relatively safe.

However, because NMNH is a newer supplement, it’s best to consult with a healthcare provider before using it, especially if you have any pre-existing health conditions.

Benefits Of NMNH

Higher Levels Of Nad+

NMNH helps to increase NAD+ levels in the body quickly and effectively. This is crucial because NAD+ plays a role in many important physiological processes, such as energy metabolism and DNA repair.

Moreover, NMNH is more effective than NMN because it doesn’t need to go through the NRK and NAMPT metabolic pathways like NMN and NR do. Instead, NMNH is metabolized through an independent pathway, making it even more efficient [4].

Reduction In Weight

NMNH helps control energy metabolism by inhibiting glycolysis and the TCA cycle – two main energy-producing pathways. When energy metabolism is controlled, the body stores fewer calories, which can support weight maintenance or even weight loss [5].

May Decrease High Blood Pressure

Supplementing with NMNH can increase NAD+ levels in the body. And good NAD+ levels can help improve blood vessel function and reduce inflammation, which can regulate blood pressure and reduce the risk of cardiovascular disease. Thus, another benefit of NMNH is its potential to lower high blood pressure [6].

Enhanced Strength

NMNH helps increase NAD+ levels in the body much faster and more effectively than precursors like NMN or NR. This helps cells recover better and combat age-related damage, particularly benefiting kidney health and damaged tissues. It makes the body healthier, supports energy, and improves strength from the inside [7].

Help Lowered Healthy Cholesterol Levels

NAD+ can help increase good cholesterol and reduce bad cholesterol, and by using NMNH, you can boost NAD+ levels, which can effectively improve healthy cholesterol levels already within normal range. This helps improve heart health and reduces the risk of cholesterol-related diseases [8].

NMNH Potential Side Effects

Some people may experience mild side effects such as nausea, diarrhea, or flushing when using NMNH. Currently, there is limited research on the safety of NMNH in humans, so it's important to consult with a healthcare professional before using it.

Since NMNH is a new ingredient, there is no official information on potential side effects or risks of interactions with other medications. This can be a concern if you are taking other medications and wish to use NMNH. In some cases, it may cause adverse reactions.

Additionally, because NMNH has not been approved by the Food and Drug Administration (FDA), users should consult a doctor before use, especially those with health issues, pregnant individuals, or those with liver or kidney problems.

Recommended Dosage of NMNH

In studies, NMNH dosages typically used for cells are 100 μM or 1 mM for treatment lasting 1 to 12 hours. For mice, the dose is 340 mg/kg, with a treatment duration of 6 hours [5]. However, the animal studies used injections, not oral doses, so the dosage might differ.

Currently, there is no recommended dosage for NMNH supplements. However, based on animal studies, NMNH dosages may be lower than those for NMN and NR [9].

• NMN: Safe dosage ranges from 250 to 1,250 milligrams per day.
• NR: Safe dosage ranges from 100 to 1,000 milligrams per day.

NMNH products typically contain 250-500 milligrams for daily use. However, the dosage may vary depending on the intended use. If you plan to use NMNH, it's best to consult a doctor to determine the appropriate dosage for you.

NMNH Supplements And FDA

NMNH, an alternative to NMN, is currently sold on websites like Amazon. However, the FDA has not yet made an official decision regarding the safety of NMNH. To sell NMNH as a supplement, companies must submit a New Dietary Ingredient (NDI) notification to the FDA.

Although studies suggest that NMNH may help boost NAD+ levels in the body more effectively than NMN, there is still insufficient research on its long-term safety. Therefore, consumers should be cautious when purchasing and using this product.

How To Take NMNH Supplements

NMNH supplements are typically available in capsule form. You only need to take 1 capsule daily at any time of day, making it easy to add to your daily routine. The capsule can be swallowed directly with water and does not need refrigeration. Store the product in a dry, cool place and keep it away from light.

Nowadays, NMNH supplement formulas are becoming more diverse and offer greater benefits. Some supplements combine NMNH with NR (Nicotinamide Riboside) and TNG (Tetrahydrocurcumin), which significantly enhance energy, anti-aging effects, and cellular protection compared to other products.

Part of the reason is that NMNH and NR support cellular health, while TNG, a powerful antioxidant, provides comprehensive health benefits.

Conclusion

NMNH is a promising supplement that can boost NAD+ levels and offer several health benefits, from weight loss to heart health support.

While NMNH is considered safe, it’s best to consult a doctor before using it to ensure it’s effective and safe for your health. Remember, NMNH is not a medication, and it can only support you in your health journey!