Cistanche Vs Tongkat Ali: The Comprehensive Comparison
Tongkat Ali is renowned for its ability to boost testosterone levels, while Cistanche, though less well-known, stands out for its capacity to enhance cognitive brain health.
Although both herbs share similar beneficial properties, they differ in their specific advantages. Let's compare these two famous herbs in the following article!
Before exploring further, please read the disclaimer located at the end of this webpage.
Key Takeaways
- Tongkat Ali is considered more effective than Cistanche in boosting testosterone levels and enhancing workout performance.
- On the other hand, Cistanche stands out for its ability to support cognitive and brain health.
- Both Cistanche and Tongkat Ali are widely used in traditional and modern medicine for men's health.
- Cistanche vs. Tongkat Ali: Choosing between these two herbs depends on individual needs.
- Alternatively, users can opt for quality products that combine both herbs for a broader range of benefits.
Cistanche vs Tongkat Ali - Key Differences
The Origin of Cistanche Tubulosa and Tongkat Ali
Tongkat Ali, native to Southeast Asian countries like Vietnam, Malaysia, Thailand, and Indonesia, has gradually gained popularity worldwide as a prominent herbal medicine. It has mainly gained recognition in European and American countries.
Cistanche, a resilient shrub-like plant, is indigenous to Japan, Indonesia, China, and Malaysia. Its unique appearance resembles a blend of pine and pineapple trees originating from the desert regions of Mongolia and northern China.
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The Population and Scientific Studies
Tongkat Ali, or Eurycoma Longifolia Jack, has garnered significant attention from researchers due to its potential benefits. Numerous studies have provided evidence of its effectiveness.
Tongkat ali is beneficial for testosterone, sexual health and appears to improve erectile dysfunction and fertility. Besides, this plant also has the effect of fighting stress, anxiety, and inflammation. [1]
In contrast, Cistanche needs more research and attention.
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Traditional Use
For centuries, Tongkat Ali has been utilized in traditional medicine to address male reproductive health concerns, boost energy levels, and reduce stress.
Similarly, in Chinese medicine, Cistanche has a rich history of use in improving sexual health, supporting kidney and liver function, and enhancing overall energy levels.
The Active Compounds
Tongkat Ali contains several critical bioactive compounds, including quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, and bioactive steroids. [2]
Among these, the quassinoid compounds are a significant part of the Eurycoma longifolia root. These compounds contribute to various health benefits of Tongkat Ali, such as increased energy, improved sexual performance, and overall vitality.
Recent scientific research has revealed that Cistanche deserticola contains various chemical constituents, including phenylethanoid glycosides, iridoid glycosides, lignans, polysaccharides, amino acids, and volatile compounds. [3]
These compounds are recognized for their remarkable antioxidant and anti-inflammatory properties, contributing to the potential benefits of Cistanche for health.
Read more: Is Combining DHEA And Tongkat Ali Together A Good Idea?
The Comparison Between Cistanche and Tongkat Ali Benefits
Improved Athletic Performance and Muscle Development
This herb is scientifically proven to boost athletic performance due to its powerful adaptogenic and anabolic properties.
These properties aid in Tongkat Ali's testosterone levels effects and restore energy to optimal levels during physical activity. [5]
A study involving 40 men in 2015 demonstrated that consuming 400mg of Tongkat Ali daily for 8 weeks significantly improved muscle strength and overall power output [4].
While research on Cistanche's effects on athletic performance and muscle development is limited, available studies indicate its potential benefits.
Consuming Cistanche Deserticola can help reduce muscle damage, delay lactic acid buildup, and improve energy levels. Additionally, Cistanche promotes glycogen storage in muscles after exercise.
Glycogen, the stored form of glucose, is a vital energy source for cells. Increased glycogen levels facilitate faster recovery and reduce post-workout soreness [6].
Both Tongkat Ali and Cistanche offer unique benefits for enhancing athletic performance and muscle development, contributing to overall health and well-being.
Enhancing Sexual Performance and Desire
Both Tongkat Ali and Cistanche have shown positive effects on male sexual health. While there is more research on the sexual performance benefits of Tongkat Ali, this does not mean that Cistanche is less effective.
Cistanche, often referred to as Genghis Khan’s Favorite Herb, has been proven to increase sperm count and motility while boosting sex hormones by producing testicular steroidogenic enzymes [17].
In traditional Chinese medicine, Cistanche has been used to address reproductive and sexual issues such as impotence and female infertility. Some studies also suggest that Cistanche's sexual benefits include creating a smooth and balanced sexual vitality [18].
Choosing between Tongkat Ali and Cistanche for sexual health is not straightforward, as both have strong historical and scientific backing.
Improving Cognitive and Neurological Function
Cistanche is generally considered more effective than Tongkat Ali in enhancing brain, neurological, and cognitive functions. This benefit is attributed to compounds called echinacosides and acteosides found in Cistanche.
A study titled "Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro" concluded that
C. tubulosa nanopowder exerted protective effects in dopaminergic neurons in both in vitro and in vivo and increased TH expression to improve DA content. [19].
Optimized Adrenal Function and Effective Stress Control
Both Tongkat Ali and Cistanche have demonstrated the ability to improve stress levels in numerous studies and are widely recognized by users for their effectiveness.
A key similarity between these two adaptogens is their impact on cortisol, a hormone produced by the adrenal glands that plays a crucial role in stress control, metabolism, immune response, blood pressure regulation, and the body's fight-or-flight response.
However, prolonged stress can lead to chronically elevated cortisol levels, which can negatively affect human health.
In a study involving individuals with everyday stress, Tongkat Ali supplementation led to a significant 11% reduction in cortisol levels [7].
This adaptogen also shows substantial potential in restoring hormonal balance, specifically in cortisol and testosterone levels, and improving mood states in response to modern stressors such as aging, diet, and exercise [9].
About Cistanche, according to a report, 48 weeks of Cistanche extract supplementation at 300 mg/day improved cognitive function in subjects with moderate Alzheimer's disease.
The data suggests that combining Cistanche (300 mg) with ginkgo (120 mg) may help alleviate mental fatigue, and increasing the dose by 50% could further enhance these benefits [8].
A 2017 study investigating the antidepressant effects of herbal decoctions from Cistanche Deserticola revealed that the herbal decoction increased nervous excitability while lowering serum corticosterone (CORT) levels.
These findings indicate reduced stress levels in rats, suggesting that Cistanche may be a valuable complementary and alternative therapy for depression [10].
Both Tongkat Ali and Cistanche offer unique benefits in managing stress and improving overall well-being through their effects on cortisol and other hormonal balances.
Learn more: Cistanche Vs. Shilajit: The Comprehensive Comparison
Side Effects Need To Be Aware
Both herbs may have possible adverse effects.
In human studies of Tongkat Ali, daily doses ranging from 200 to 600 mg have shown minimal side effects, primarily affecting the stomach.
These effects are generally mild and may include mild digestive symptoms and itching [11]. However, the occurrence of side effects is uncommon [12].
Regarding Cistanche, any potential clinical reactions are generally mild and may include symptoms such as nausea, vomiting, abdominal pain, and dizziness [13].
Additionally, there is a lack of research on the impact of Cistanche and Tongkat Ali on children, pregnant women, and breastfeeding women. As a result, the safety of this treatment for these specific groups remains uncertain.
Also read: Shilajit Vs Tongkat Ali - Difference vs Surprised Combination
Differences On Dosage
For most healthy adults, a daily dose of 200–400 mg of Tongkat Ali seems safe. [14]
As per the 2021 report by the Council on Nutrition, Novel Foods, and Food Allergens of the European Food Safety Authority (EFSA), the consumption of high doses of Tongkat Ali (2,000 mg/kg body weight) may result in DNA damage to the tissues of the stomach and duodenum [15].
Due to a lack of extensive clinical trials on Cistanche, determining the optimal dosage has proven challenging.
A study on animals discovered that administering 50 mg/kg of Cistanche yielded significant anti-inflammatory, antioxidant, and cognitive protective effects in rats.
According to the conversion chart for dosage between animals and humans, this translates to a recommended daily dose of Cistanche ranging from 400mg to 800mg for most individuals [16].
These findings highlight the potential benefits of Cistanche and its potential application in promoting overall well-being.
Cistanche Vs Tongkat Ali: Choosing The Right One
Both Cistanche and Tongkat Ali possess properties that promote human health.
While Tongkat Ali is primarily recognized for its potential to increase testosterone levels, Cistanche is renowned for its cognitive-enhancing and adaptogenic effects. This especially contributes to Cistanche's benefits for women.
Tongkat Ali may be the preferred choice when addressing hormonal imbalances due to its ability to regulate cortisol and testosterone levels.
On the other hand, Cistanche's remarkable anti-inflammatory and antioxidant properties make it a suitable option for individuals seeking to enhance overall brain health.
Regarding safety, Tongkat Ali has undergone extensive human trials with few reported side effects. However, due to the limited research on Cistanche, it is essential to consult a healthcare professional before incorporating it into your daily routine.
Ultimately, the selection between Tongkat Ali and Cistanche will depend on the individual's specific health needs and preferences.
Can You Combine Cistanche and Tongkat Ali?
Indeed, Tongkat Ali and Cistanche can yield a potent blend. These remarkable herbs serve as testosterone boosters and can complement each other perfectly. When taken together, they have shown no negative interactions to date.
This herbal fusion holds immense potential in enhancing testosterone levels, increasing energy production, and promoting optimal mental well-being. It is a powerful synergy that can unlock numerous benefits for optimizing their health and vitality.
Conclusion
Cistanche and Tongkat Ali are two potent herbs that offer various health benefits. Tongkat Ali is known for its potential to address hormonal imbalances, while Cistanche may enhance brain health and cognitive function.
Nevertheless, it is essential to be aware of the possible side effects associated with these herbs.
Adhering to the recommended dosage is crucial. Prioritizing consultation with a healthcare professional is always advised.
References
- [1] Shaheed Ur Rehman, Kevin Kyungsik Choe, & Hye Hyun Yoo. (2016). Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules, 21(3), 331–331. https://doi.org/10.3390/molecules21030331
- [2] Lee, E. L., & Barnes, J. (2022). Tongkat Ali/Long Jack. Journal of Primary Health Care. https://doi.org/10.1071/hc22143
- [3] Cheng, N., Wang, H., Huang, H., Rahman, F.-U., & Zhang, Y. (2023). Research progress on polysaccharide components of Cistanche deserticola as potential pharmaceutical agents. European Journal of Medicinal Chemistry, 245, 114892–114892. https://doi.org/10.1016/j.ejmech.2022.114892
- [4] Foong Kiew Ooi, Mohamed Husna Afifah, Chee Keong Chen, & Mohd Asnizam Asari. (2015, March 15). Combined effects of Eurycoma longifolia Jack supplementation and a circuit training programme on bone... ResearchGate; unknown. https://www.researchgate.net/publication/273645648_Combined_effects_of_Eurycoma_longifolia_Jack_supplementation_and_a_circuit_training_programme_on_bone_metabolism_markers_muscular_strength_and_power_and_immune_functions_in_adult_men
- [5] Henkel, R., Wang, R., Bassett, S., Chen, T., Liu, N., Zhu, Y., & Mohd. (2013). Tongkat Ali as a Potential Herbal Supplement for Physically Active Male and Female Seniors-A Pilot Study. Phytotherapy Research, 28(4), 544–550. https://doi.org/10.1002/ptr.5017
- [6] Cai, R., Yang, M., Shi, Y., Chen, J., Li, Y., & Qi, Y. (2009). Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola. Phytotherapy Research, 24(2), 313–315. https://doi.org/10.1002/ptr.2927
- [7] View of Effect of Eurycoma longifolia standardised aqueous root extract– Physta® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicentre study | Food & Nutrition Research. (2023). Foodandnutritionresearch.net. https://foodandnutritionresearch.net/index.php/fnr/article/view/5647/13561
- [8] Guo, Q., Zhou, Y., Wang, C.-J., Huang, Y.-M., Lee, Y.-T., Su, M.-H., & Lu, J. (2013). An Open-Label, Nonplacebo-Controlled Study on Cistanche tubulosa Glycoside Capsules (Memoregain®) for Treating Moderate Alzheimer’s Disease. American Journal of Alzheimer’s Disease & Other Dementias®, 28(4), 363–370. https://doi.org/10.1177/1533317513488907
- [9] Talbott, S., Talbott, J. A., George, A., & Pugh, M. (2013). Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 10(1). https://doi.org/10.1186/1550-2783-10-28
- [10] Wang, D., Wang, H., & Gu, L. (2017). The Antidepressant and Cognitive Improvement Activities of the Traditional Chinese HerbCistanche. Evidence-Based Complementary and Alternative Medicine, 2017, 1–9. https://doi.org/10.1155/2017/3925903
- [11] Leisegang, K., Finelli, R., Sikka, S. C., & Manesh. (2022). Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Medicina-Lithuania, 58(8), 1047–1047. https://doi.org/10.3390/medicina58081047
- [12] Surachai Kotirum, Ismail, R., & Nathorn Chaiyakunapruk. (2015). Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: Systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 23(5), 693–698. https://doi.org/10.1016/j.ctim.2015.07.009
- [13] Gu, C., Yang, X., & Huang, L. (2016). Cistanches Herba: A Neuropharmacology Review. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00289
- [14] Ismail, R., Mohd, W., George, A., Hussain, N., Kamal, M., & Liske, E. (2012). Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract ofEurycoma longifoliafor the Improvement of Quality of Life and Sexual Well-Being in Men. Evidence-Based Complementary and Alternative Medicine, 2012, 1–10. https://doi.org/10.1155/2012/42926
- [15] NULL AUTHOR_ID, Turck, D., Bohn, T., Castenmiller, J., Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Alexandre Maciuk, Mangelsdorf, I., McArdle, H. J., Androniki Naska, Peláez, C., Pentieva, K., Siani, A., Thiès, F., Tsabouri, S., Vinceti, M., Cubadda, F., Frenzel, T., Heinonen, M., & Miguel Prieto Maradona. (2021). Safety of Eurycoma longifolia (Tongkat Ali) root extract as a novel food pursuant to Regulation (EU) 2015/2283. EFSA Journal, 19(12). https://doi.org/10.2903/j.efsa.2021.6937
- [16] Nair, A. B., & Jacob, S. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27–27. https://doi.org/10.4103/0976-0105.177703
- [17] Cistanche tubulosa ethanol extract mediates rat sex hormone levels by induction of testicular steroidgenic enzymes. (2016). Pharmaceutical Biology. https://doi.org/10.3109//13880209.2015.1050114
- [18] Li, Z., Lin, H., Gu, L., Gao, J., & Tzeng, C.-M. (2016). Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00041
- [19] Xu, Q., Fan, W., Ye, S.-F., Cong, Y.-B., Qin, W., Chen, S.-Y., & Cai, J. (2016). Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Apoptosis and Glial Cell-Derived Neurotrophic Factor: in vivo and in vitro. Frontiers in Aging Neuroscience, 8. https://doi.org/10.3389/fnagi.2016.00295
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